Results 91 to 100 of about 662,847 (267)

Impact of the Cosmic Web on the Properties of Galaxies in IllustrisTNG Simulations

The Astrophysical Journal
We investigate the influence of the cosmic web on galaxy properties in the IllustrisTNG simulations. To disentangle the effects of galaxy groups and cosmic filaments, we divide the cosmic web environment into four categories: group, group-dominated ...
Guangyao Yu, Weishan Zhu, Qi-Rui Yang, Jian-Feng Mo, Tian-Cheng Luan, Long-Long Feng   +5 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Galaxy groups within voids

Astronomy & Astrophysics
Context. Despite cosmic voids being vast and almost empty, galaxy aggregations do exist within them, although they are much sparser than in denser regions like walls, filaments, and clusters.
Argudo-Fernández M., Torres-Ríos G., Vásquez-Bustos P., Verley S., Pérez I., Duarte Puertas S., Jiménez A., García-Benito R., Zurita A., Alcázar-Laynez M., Bidaran B., Conrado A., Espada D., Florido E., González Delgado R., Hernández-Sánchez M., del Moral-Castro I., Román J., Sánchez-Menguiano L., Subramanian S., Villalba-González P.   +20 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Strong Trotter Property for Locally μ-Convex Lie Groups

Journal of Lie Theory, 2020
We show that an infinite dimensional Lie group in Milnor's sense has the strong Trotter property if it is locally $μ$-convex. This is a continuity condition imposed on the Lie group multiplication that generalizes the triangle inequality for locally convex vector spaces, and is equivalent to $C^0$-continuity of the evolution map on its domain.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

On a family of Wiener type spaces

International Journal of Mathematics and Mathematical Sciences, 1996
Research on Wiener type spaces was initiated by N.Wiener in [15]. A number of authors worked on these spaces or some special cases of these spaces. A kind of generalization of the Wiener's definition was given by H.Feichtinger in [2] as a Banach spaces ...
R. H. Fischer, A. T. Gürkanli, T. S. Liu   +2 more
doaj   +1 more source

Local to global property in free groups

, 2019
The local to global property for an equation $ψ$ over a group G asks to show that $ψ$ is solvable in G if and only if it is solvable in every finite quotient of G. In this paper we focus that in order to prove this local to global property for free groups $G=F_k$, it is enough to prove for k less or equal the number of parameters in $ψ$.
openaire   +2 more sources