Results 131 to 140 of about 9,166,026 (293)

On the Cryptographic Hardness of Local Search.

open access: yesIACR Cryptol. ePrint Arch., 2020
We show new hardness results for the class of Polynomial Local Search problems (PLS): - Hardness of PLS based on a falsifiable assumption on bilinear groups introduced by Kalai, Paneth, and Yang (STOC 2019), and the Exponential Time Hypothesis for randomized algorithms.
Nir Bitansky, Idan Gerichter
openaire   +4 more sources

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach   +23 more
wiley   +1 more source

Complete local search with memory [PDF]

open access: yes
Neighborhood search heuristics like local search and its variants are some of the most popular approaches to solve discrete optimization problems of moderate to large size. Apart from tabu search, most of these heuristics are memoryless. In this paper we
Sierksma, G., Ghosh, D.
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu   +7 more
wiley   +1 more source

Accelerating AutoDock4 with GPUs and Gradient-Based Local Search. [PDF]

open access: yesJ Chem Theory Comput, 2021
Santos-Martins D   +5 more
europepmc   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen   +6 more
wiley   +1 more source

Utilizing Problem Structure in Planning:

open access: yes, 2003
The book deals with general problem solving in the form given by the STRIPS planning formalism. Planning systems read in a STRIPS problem description, and then perform the search for a solution fully automatically, i.e., without any knowledge about the ...
Local Search Approach, Jorg Hoffmann
core  

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