Results 51 to 60 of about 681,060 (327)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Efficient Hill Climber for Multi-Objective Pseudo-Boolean Optimization [PDF]

, 2016
Chicano, F., Whitley D., & Tinós R. (2016). Efficient Hill Climber for Multi-Objective Pseudo-Boolean Optimization. 16th European Conference on Evolutionary Computation for Combinatorial Optimization (LNCS 9595), pp.
Chicano, Francisco, Tinós, Renato, Whitley, Darrell   +2 more
core  

Exploiting Local Optimality in Metaheuristic Search

CoRR, 2020
A variety of strategies have been proposed for overcoming local optimality in metaheuristic search. This paper examines characteristics of moves that can be exploited to make good decisions about steps that lead away from a local optimum and then lead toward a new local optimum.
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Optimality of Geometric Local Search.

, 2018
Up until a decade ago, the algorithmic status of several basic NP-complete problems in geometric combinatorial optimisation was unresolved. This included the existence of polynomial-time approximation schemes (PTASs) for hitting set, set cover, dominating set, independent set, and other problems for some basic geometric objects.
Bruno Jartoux, Nabil H. Mustafa
openaire   +4 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Optimization in timetabling in schools using a mathematical model, local search and Iterated Local Search procedures

Gestão & Produção
This paper addresses the school timetabling problem, which consists of defining the date and time in which classes will be given by teachers in educational institutions.
Pedro Rochavetz de Lara Andrade, Maria Teresinha Arns Steiner, Anderson Roges Teixeira Góes   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Evolutionary multiobjective optimization via efficient sampling-based offspring generation

Complex & Intelligent Systems, 2023
With the rising number of large-scale multiobjective optimization problems from academia and industries, some evolutionary algorithms (EAs) with different decision variable handling strategies have been proposed in recent years. They mainly emphasize the
Cheng He, Lianghao Li, Ran Cheng, Yaochu Jin   +3 more
doaj   +1 more source

Optimization by thermal cycling

, 2005
Thermal cycling is an heuristic optimization algorithm which consists of cyclically heating and quenching by Metropolis and local search procedures, respectively, where the amplitude slowly decreases.
A. Díaz-Sánchez, A. Fachat, A. Möbius, A. Möbius, A. Möbius, A. Neklioudov, B. A. Huberman, B. Freisleben, D. S. Johnson, E. Balas, F. P. Marín, F.-M. Dittes, G. Reinelt, H. Bersini, H. Mühlenbein, J. Schneider, K. H. Hoffmann, M. Jünger, M. Jünger, M. Schreiber, N. Metropolis, O. C. Martin, O. Martin, P. Merz, P. van Laarhoven, S. Kirkpatrick, S. Lin, Z. Li   +27 more
core   +2 more sources