Results 131 to 140 of about 26,442 (265)

Pneumococcal Sepsis Revealing Pediatric Systemic Lupus Erythematosus with Sjögren's Syndrome Overlap: A Case Report. [PDF]

Pediatr Rep
Accomando F, Albertazzi V, Girelli F, Biscarini M, Aricò MO, Valletta E.   +5 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Localism [PDF]

, 2018
openaire   +2 more sources

A new unfolded pocket mesh for pre-pectoral direct to implant breast reconstruction: first case report. [PDF]

J Surg Case Rep
Formica S, De Riggi MA, Polverino G, Russo F, Rocco N, Panico MP, D'aiuto M, D'Andrea F.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exploring the mysterious behavior of the critically endangered South African Wolkberg Zulu butterfly (<i>Alaena margaritacea</i>) using micro-CT scanning and morphological analysis (Lycaenidae: Liptenini). [PDF]

PeerJ
Sihvonen P, Söderholm M, Oudendijk Z, Villet MH, Terblanche E.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Hemodialysis Central Venous Catheter-Associated Bloodstream Infection Caused by <i>Stenotrophomonas maltophilia</i> Treated with Cefiderocol and Levofloxacin After Failure of Trimethoprim-Sulfamethoxazole Monotherapy and Device Replacement. [PDF]

Antibiotics (Basel)
Meini S, Antonelli A, Longo B, Mura M, Andreoli E, Kanaki A, Grassi G, Niccolai C, Viaggi B, Rossolini GM.   +9 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

MISAPSY: childhood maltreatment, food insecurity, psychological distress and professional integration among socioeconomically disadvantaged young adults - a mixed-methods study protocol. [PDF]

BMC Psychol
Cappelletti M, Mathieu J, Musso M, Shadili G, Bernateau I, Bazan A, Robin M, Essadek A.   +7 more
europepmc   +1 more source