Results 61 to 70 of about 1,777,283 (248)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa   +7 more
wiley   +1 more source

Signal control using vehicle localization probe data

open access: yes, 2010
This paper presents a simulation test bed and methodology for evaluating urban signalized junction control algorithms that use localization probe data from all vehicles in the local area.
Waterson, B.J., Box, S.
core   +1 more source

Constructing a Russian-Language Version of the International Early Reading Assessment Tool

open access: yesВопросы образования, 2019
Successful adaptation of first-graders to school largely determines their subsequent educational attainment. In Russia as well as across the globe, there are few high-quality standardized assessment instruments providing comprehensive vision of what ...
Alina Ivanova   +1 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Radio-Wave Based Accurate Localization for Space Rover on Small Planetary Body without Motion Information of Mother Spacecraft

open access: yesSICE Journal of Control, Measurement, and System Integration, 2017
Investigations of small planetary bodies (SPBs) such as asteroids and comets have attracted increasing attention recently. In our previous research, a method to localize a space rover was proposed.
Sayaka Kanata   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Underwater Localization via Wideband Direction-of-Arrival Estimation Using Acoustic Arrays of Arbitrary Shape

open access: yesSensors, 2020
Underwater sensing and remote telemetry tasks necessitate the accurate geo-location of sensor data series, which often requires underwater acoustic arrays. These are ensembles of hydrophones that can be jointly operated in order to, e.g., direct acoustic
Elizaveta Dubrovinskaya   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Clothoid: An Integrated Hierarchical Framework for Autonomous Driving in a Dynamic Urban Environment

open access: yesSensors, 2020
In recent years, research and development of autonomous driving technology have gained much interest. Many autonomous driving frameworks have been developed in the past.
Saba Arshad   +4 more
doaj   +1 more source

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