Results 31 to 40 of about 168,312,063 (201)

Investigation of Fractional Behaviors for Physical Phenomena Equation and Ion-Acoustic Wave Equation via Generalized Bernoulli Equation Method

Computational and Mathematical Methods
This research explores the fractional dynamics of two important nonlinear models: the (2+1)-dimensional breaking soliton equation, which arises in the description of various physical phenomena such as shallow-water waves, plasma oscillations, and optical
Weerachai Thadee, Pakakrong Tapparak, Panupong Vichitkunakorn, Anak Nongmanee, Sirasrete Phoosree   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A comprehensive review on natural convection in various shaped enclosures by FEM: Engineering applications

South African Journal of Chemical Engineering
Natural convection within enclosed cavities plays a critical role in heat and mass transfer across a wide range of engineering applications. Buoyancy flows are a fundamental aspect of many optimized systems currently deployed, including passive cooling ...
Asif Hasan, Mohammad Mokaddes Ali, Shakhawat Hossain, Neamul Haque Siam, Asaduzzaman Rony, Al-Amin Shohan   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Heat Transfer in n‐Dimensional Parallelepipeds Under Zero Dirichlet Conditions

Engineering Reports
This article presents a comprehensive analytical study of heat propagation in an n‐dimensional bounded domain subject to zero Dirichlet boundary conditions, corresponding to a thermally insulated parallelepiped with internal heat sources. While classical
Zafar Duman Abbasov, Davron Aslonqulovich Juraev, Obidjon Khayrullaevich Abdullaev, Irfan Nurhidayat, Mohd Asif Shah   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A General Finite Beam on Tensionless Foundation Model for Rail Track Characterization and Evaluation

Sensors
Rail infrastructure plays an important role in freight and passenger mobility, and the assessment of rail track structure depends critically on understanding how the rail interacts with the supporting foundation.
Hamoud H. Alshallaqi, Brett A. Story
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A global spacetime optimization approach to the real-space time-dependent Schrödinger equation

Machine Learning: Science and Technology
The time-dependent Schrödinger equation (TDSE) in real space is fundamental to understanding the dynamics of many-electron quantum systems, with applications ranging from quantum chemistry to condensed matter physics and materials science.
Enze Hou, Yuzhi Liu, Linxuan Zhang, Difa Ye, Lei Wang, Han Wang   +5 more
doaj   +1 more source