Results 51 to 60 of about 15,405 (218)

Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression. [PDF]

, 2018
Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal role in the clinical presentation of these conditions.
Chan, JSK, Chen, J.P., Chiba, S., Koh, NJN, Ng, X.R., Pal, M., Phua, T., Sng, M.K., Tan, C.K., Tan, EHP, Tan, N.S., Teo, Z., Tnay, Y.L., Tong, BMK, Wahli, W., Wang, X., Wee, JWK, Zhu, P.   +17 more
core   +4 more sources

Assessment of Treatment Response in Patients With Scleromyxedema by the Double Modified Rodnan Skin Score

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Scleromyxedema (SMX) is a cutaneous mucinosis characterised by an abnormal accumulation of mucin in the skin and limited treatment options. Assessment of therapy response during treatment is challenging. Objectives Patients with SMX receiving high‐dose intravenous IVIg therapy were included to assess validity of the double modified ...
Julia K. Winkler, Alexander H. Enk
wiley   +1 more source

Evaluation of mean platelet volume in localized scleroderma [PDF]

Anais Brasileiros de Dermatologia, 2017
: Background: Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation.
Anil Gulsel Bahali, Ozlem Su, Nazan Emiroglu, Fatma Pelin Cengiz, Mehmet Onur Kaya, Nahide Onsun   +5 more
doaj   +1 more source

Capillaroscopy in 2016 : new perspectives in systemic sclerosis [PDF]

, 2016
Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc.
Cutolo, M, Llado, A, Paolino, S, Pizzorni, C, Ruaro, B, Smith, Vanessa, Sulli, A   +6 more
core   +1 more source

Quantitative nanohistological investigation of scleroderma: An atomic force microscopy-based approach to disease characterization [PDF]

, 2017
Scleroderma (or systemic sclerosis, SSc) is a disease caused by excess crosslinking of collagen. The skin stiffens and becomes painful, while internally, organ function can be compromised by the less elastic collagen.
Aguayo, S, Ahmed, T, Bozec, L, Mordan, N, Parekh, S, Porter, SR, Strange, AP, Stratton, R   +7 more
core   +1 more source

Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective

JEADV Clinical Practice, EarlyView.
Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek, Iris Zalaudek, Karolina Zarańska, Bożena Cybulska‐Stopa   +3 more
wiley   +1 more source

Localized scleroderma – classification and tools used for the evaluation of tissue damage and disease activity/severity

Przegląd Dermatologiczny, 2017
Localized scleroderma is a rare autoimmune disorder affecting the dermis, subcutaneous tissue and deeper structures. The course of localized scleroderma includes three stages: early inflammation, progressive sclerosis and atrophy. The active stage of the
Katarzyna Wolska-Gawron, Dorota Krasowska   +1 more
doaj   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Juvenile localized scleroderma with port wine stain: Coincidental or possible common pathogenetic association

Indian Journal of Dermatology, 2015
Port wine stain and juvenile localized scleroderma are two different dermatoses usually encountered in pediatric age group. Up to now, there are reports of morphea patients initially diagnosed and treated as port wine stain.
Seval Dogruk Kacar, Pinar Ozuguz, Serap Polat, Emre Kacar, Onur Polat, Cigdem Tokyol   +5 more
doaj   +1 more source

A proposed scoring system for assessing the severity of actinic keratosis on the head: actinic keratosis area and severity index [PDF]

, 2017
Background: Actinic keratosis (AK) severity is currently evaluated by subjective assessment of patients. Objectives: To develop and perform an initial pilot validation of a new easy-to-use quantitative tool for assessing AK severity on the head ...
Arkachaisri, Benzekri, Chams-Davatchi, Chen, Chetty, Cockerell, Consensus Report of the European Task Force on Atopic Dermatitis, Feily, Fernandez-Figueras, Fredriksson, Green, Green, Ianhez, Langley, Lee, Mlynek, O'Brien, Olsen, Pandya, Röwert-Huber, Schaefer, Schmitz, Stockfleth, Taieb, Uhlenhake, Wei, Werner, Wolf   +27 more
core   +1 more source