Results 101 to 110 of about 8,123,913 (272)
Emu - Austral Ornithology, 1928 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
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Locally Constant Nonproduct-Type Cocycles
Journal of Functional Analysis, 1998 Let \({\mathcal A}\) denote an UHF algebra realized as a \(C^\ast\)-algebra \(C^\ast({\mathcal R})\) of continuous functions on a groupoid \({\mathcal R}\), and let \(d\) denote a continuous real-valued 1-cocycle on \({\mathcal R}\) (a continuous homomorphism \(d:{\mathcal R}\to {\mathbb R}\)) implementing an automorphism group \(\alpha^d\) of ...
Ventura, Belisario A, Wagner, Bruce H
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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On algebras of second local type. III
Osaka Journal of Mathematics, 1984 An artinian ring A with 1 and Jacobson radical J is called ``of second local type'', if for every indecomposable right A-module M the factor module \(M/MJ^ 2\) is indecomposable. Here the author continues his investigations on rings of this type published in previous papers [ibid. 21, 327-342 and 343-364 (1984; Zbl 0547.16010)].
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Type localities of the Megathymidae
The Journal of Research on the Lepidoptera, 1963 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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