Results 51 to 60 of about 8,123,913 (272)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
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, 1962 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
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, 2023 This exploration delves into the diverse landscape of local anesthetics, shedding light on the various types that play a crucial role in pain management during medical procedures. From lidocaine to bupivacaine, this article navigates through the mechanisms, applications, and considerations associated with different classes of local anesthetics ...
Bobomurodov Shohjaxon Baxriddin o'g'li +1 more
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Methotrexate: an effective monotherapy for refractory generalized morphea
Clinical, Cosmetic and Investigational Dermatology, 2017 Eftychia Platsidaki, Vassiliki Tzanetakou, Anargyros Kouris, Panagiotis G Stavropoulos Department of Dermatology and Venereology, Andreas Syggros Hospital, University of Athens, Athens, Greece Introduction: Morphea is an inflammatory skin ...
Platsidaki E +3 more
doaj
E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast. [PDF]
PLoS ONE, 2014 We previously identified three glycosylphosphatidylinositol (GPI)-anchored proteins including Ecm33, as multicopy suppressors of the phenotypes of a mutant allele of cis4(+) that encodes a zinc transporter in fission yeast.
Yue Fang +8 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
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On the representaion type of locally bounded categories [PDF]
Tsukuba Journal of Mathematics, 1986 Let K be an algebraically closed field. Given a K-algebra R we denote by mod(R) the category of finite dimensional right R-modules. We recall that R is representation-tame if for every \(d>0\) there are K[T]-R-bimodules \(_{K[T]}Q_ R^{(j)}\), \(j=1,...,m_ d\), such that: (i) \(_{K[T]}Q^{(j)}\) is finitely generated free, (ii) all but a finite number of
Dowbor, Piotr, Skowronski, Andrzej
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Extranodal Natural Killer/T-Cell Lymphoma of the Nasal Type with Skin Metastases
Case Reports in Oncology, 2016 Extranodal natural killer/T-cell lymphoma (ENKL) of the nasal type is a rare, clinically aggressive disease. ENKL of the nasal type is often localized in the upper aerodigestive tract, including the nasal cavity, nasopharynx, paranasal sinuses, tonsils ...
Fadi Al Akhrass +3 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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