Results 41 to 50 of about 137,024 (263)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Salvage low-dose-rate brachytherapy for locally recurrent prostate cancer after definitive irradiation

open access: yesClinical and Translational Radiation Oncology
Purpose: The optimal management of locally recurrent prostate cancer after definitive irradiation is still unclear but local salvage treatments are gaining interest.
Y. Meraouna   +9 more
doaj   +1 more source

A generalized integrability problem for G-Structures

open access: yes, 2015
Given an $\widetilde n$-dimensional manifold $\widetilde M$ equipped with a $\widetilde G$-structure $\widetilde\pi:\widetilde P\rightarrow \widetilde M$, there is a naturally induced $G$-structure $\pi: P\rightarrow M$ on any submanifold $M\subset ...
Santi, Andrea
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

On difficult problems and locally graded groups

open access: yesJournal of Mathematical Sciences, 2007
A group \(G\) is called an LG-group if any non-trivial finitely generated subgroup in \(G\) has a proper subgroup of finite index. It is known that the class of LG-groups is closed with respect to taking subgroups, extensions and Cartesian products. This class also contains all groups whose finitely generated subgroups are LG-groups and all groups that
openaire   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Groups with the Infinite Non-Quasicentral Nodal Subgroup

open access: yesCommunications, 2014
We present some properties of the groups with the infinite non-quasicentral periodic nodal subgroup. Our main results are formulated in Theorem 1, 2 and Theorem 3, 4.
Ludovit Tomanek, Anna Tomankova
doaj   +1 more source

Stably dualizable groups [PDF]

open access: yes, 2005
We extend the duality theory for topological groups from the classical theory for compact Lie groups, via the topological study by J. R. Klein [Kl01] and the p-complete study for p-compact groups by T. Bauer [Ba04], to a general duality theory for stably
Rognes, John
core   +3 more sources

Grading of homogeneous localization by the Grothendieck group

open access: yes, 2023
Let $G$ be the Grothendieck group of a commutative monoid $M$. We prove that for any multiplicative set $S$ of homogeneous elements of an $M$-graded ring $R=\bigoplus\limits_{m\in M}R_{m}$, then the localization ring ...
openaire   +2 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

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