Results 41 to 50 of about 26,682 (273)
Clinical and Translational Radiation OncologyPurpose: The optimal management of locally recurrent prostate cancer after definitive irradiation is still unclear but local salvage treatments are gaining interest.
Y. Meraouna +9 more
doaj +1 more source
PLoS ONE, 2019 BackgroundPositive mindset (PM) is an important domain of health-related quality of life in Singapore, a multi-ethnic urban city state in Southeast Asia.
Yu Heng Kwan +12 more
doaj +1 more source
The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Infinite group-graded rings, rings of endomorphisms, and localization
Journal of Pure and Applied Algebra, 1989 Let \(R\) be a \(G\)-graded ring and \(U=\oplus_{x\in G} R(x)\), the canonical generator of the category \(R-gr\) of graded left \(R\)-modules. Then \(\text{End}_{R-gr}(U)\) is isomorphic to \(R\nabla G\), the ring of row finite \(G\times G\) matrices with entries from \(R\) such that the \(x-y\) entry is from \(R_{xy^{-1}}\). In Section 2, it is shown
Albu, Toma, Năstăsescu, Constantin
openaire +4 more sources
Locally graded groups with certain minimal conditions for subgroups, II
, 2021 This paper deals with one of the ways of studying infinite groups many of whose subgroups have a prescribed property, namely the consideration of minimal conditions.
Peña, Juan Manuel, Otal, Javier
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Milnor’s alternative for finitely generated relatively free groups that are locally graded
Rendiconti del Seminario Matematico della Università di Padova, 2020 Let G be a finitely generated relatively free group that is locally graded. We show that either G contains a non-trivial free subsemigroup or
Holubowski, Waldemar, Macedońska, Olga
openaire +2 more sources
Groups with all subgroups either modular or soluble of finite rank
, 2021 We study locally graded groups whose non-modular subgroups are soluble and satisfy some rank condition. In particular, in order to characterize locally graded groups whose subgroups are either modular or polycyclic, we describe (generalized) soluble ...
De Mari F.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source