Results 111 to 120 of about 2,657,864 (332)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Automated Destination Renewal Process for Location-Based Robot Errands

open access: yesApplied Sciences
In this paper, we propose a new approach for service robots to perform delivery tasks in indoor environments, including map-building and the automatic renewal of destinations for navigation.
Woo-Jin Lee, Sang-Seok Yun
doaj   +1 more source

Active User Authentication for Smartphones: A Challenge Data Set and Benchmark Results

open access: yes, 2016
In this paper, automated user verification techniques for smartphones are investigated. A unique non-commercial dataset, the University of Maryland Active Authentication Dataset 02 (UMDAA-02) for multi-modal user authentication research is introduced ...
Chellappa, Rama   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

A Location-Based Service Using Geometric Location Methods to Unite Mobile Users [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2016
Since the introduction of iPhone in 2007, many location-based services (LBSs) have been created and new LBSs are found every day. This research proposes yet another LBS, which is practical and was not found before to the best of authors' knowledge.
Wen-Chen Hu   +2 more
doaj  

Next-Generation EU DataGrid Data Management Services

open access: yes, 2003
We describe the architecture and initial implementation of the next-generation of Grid Data Management Middleware in the EU DataGrid (EDG) project. The new architecture stems out of our experience and the users requirements gathered during the two ...
Akos Frohner   +23 more
core   +2 more sources

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