Results 71 to 80 of about 27,207,032 (271)
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Dummy Location Generation Algorithm for User Density
Journal of Harbin University of Science and TechnologyWith the development of the Internet, location-Based Services have become an indispensable part of people's lives. However, the issue of user location security has also gained significant attention.
LI Menghan, FANG Wei, LI Lihong
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Jurnal Teknologi dan Sistem Komputer, 2015 The University is an institution that has a role and strategic position in the achievement of educational goals. Semarang, as the center of Central Java has many universities, both public and private. The obstacles are that many students like high school
Satriaji Cahyo Nugroho +2 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Service training in the agriculture equipment industry [PDF]
, 2012 Plan B Paper. 2012. Master of Science in Agricultural Education--University of Wisconsin-River Falls. Agricultural Education Department. 33 leaves. Includes bibliographical references (leaf 33).The demand for service training continues to increase in the
Treu, Emily
core
Continuous location privacy protection mechanism based on differential privacy
Tongxin xuebao, 2021 Aiming at the problem of users’ location privacy leakage caused by continuously using LBS, a road privacy level (RPL) algorithm was proposed based on road topological network, which divided the privacy level of the road sections around the sensitive ...
Hongtao LI +3 more
doaj +2 more sources
Location Privacy Preservation for Mobile Users in Location-Based Services
IEEE Access, 2019 Because location-based cyber services are increasingly found in mobile applications (e.g., social networking and maps), user location privacy preservation is essential and remains one of the several ongoing research challenges.
Gang Sun +6 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source