Results 131 to 140 of about 5,564,905 (298)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Development, implementation and first insights of a time- and location-independent longitudinal postgraduate curriculum in emergency medicine. [PDF]
GMS J Med Educ, 2018 Sauter TC +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Employee or independent contractor?. Spanish
, 2007 Title from PDF caption (viewed on December 7, 2021).Covers OCLC #1287891539, OCLC #707091328, and OCLC #461109352.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Employee or independent contractor?. Russian
, 2007 Title from PDF caption (viewed on December 7, 2021).Covers OCLC #1287891563, OCLC #461112399, and OCLC #707093305.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Employee or independent contractor?. Vietnamese
, 2011 Title from PDF caption (viewed on December 7, 2021).Covers OCLC #1287891601 and OCLC #707566229.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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