Results 181 to 190 of about 1,094,283 (268)

Do ostensive verbal signals have a unique importance when communicating with dogs? [PDF]

Evol Hum Sci
Dobos P, Lugosi CA, Pongrácz P.
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

More severe natural course of Crohn's disease in Yunnan province compared with Asian and Western countries. [PDF]

Int J Colorectal Dis
Tao Y, Li M, Li H, Sun Z, Wu J, Yang L, Ma Y, Chen X, Chen L, Liang H, Wen Y, Miao Y, Zhang F, Niu J.   +13 more
europepmc   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Circular RNA <i>circHomer1</i> mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs. [PDF]

Sci Adv
Cai Y, Zheng Z, Xu H, Zhu Y, Zepeda JC, Grueter BA, Wang X, Ku T, Duan Y, Tsang HWS, Fu WY, Fu AKY, Mellios N, Wong HH, Lai KO, Ip JPK.   +15 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Predictive modeling of hematoma expansion from non-contrast computed tomography in spontaneous intracerebral hemorrhage patients. [PDF]

Elife
Ironside N, El Naamani K, Rizvi T, El-Rabbi MS, Kundu S, Becceril-Gaitan A, Pas K, Snyder MH, Chen CJ, Langefeld C, Woo D, Mayer SA, Connolly ES, Rohde GK, VISTA-ICH, ERICH Investigators.   +15 more
europepmc   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Construction and application of a nomogram model for early stage central lymph node metastasis in papillary thyroid cancer combined with Hashimoto's thyroiditis. [PDF]

Braz J Med Biol Res
Huang Y, Zeng F, Song J, Du Y.
europepmc   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source