Results 71 to 80 of about 3,201,051 (237)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Location Prediction [PDF]

Proceedings of the 2015 ACM on Conference on Online Social Networks, 2015
Humans are social animals, they interact with different communities of friends to conduct different activities. The literature shows that human mobility is constrained by their social relations. In this paper, we investigate the social impact of a person's communities on his mobility, instead of all friends from his online social networks.
Jun Pang 0001, Yang Zhang 0016
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Bioimage-Based Prediction of Protein Subcellular Location in Human Tissue with Ensemble Features and Deep Networks

, 2020
Prediction of protein subcellular location has currently become a hot topic because it has been proven to be useful for understanding both the disease mechanisms and novel drug design.
Liu, Guang-Hui, Bichindaritz, Isabelle, Mao, Bo, Zhang, Bei-Wei, Qian, Gang, Wang, Bin   +5 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Predicting the locations of missing persons in China by using NGO data and deep learning techniques

International Journal of Digital Earth
Missing person crimes can seriously affect the well-being of Chinese families, and missing person destination prediction can help to solve this problem.
Anning Dong, Yatao Zhang, Zijin Guo, Peng Luo, Yao Yao, Jialyu He, Qia Zhu, Ying Jiang, Kailu Xiong, Qingfeng Guan   +9 more
doaj   +1 more source

Surface location error for helical mills [PDF]

, 2006
Stability and surface location error are investigated numerically for milling operations with a helical tool. A detailed mechanical model is derived that includes both surface regeneration and the helical teeth of the tool.
Bachrathy, D, Homer, ME, Insperger, T, Stepan, G   +3 more
core  

Federated LSTM-based deep learning model for privacy-preserving predictions of human trajectories across multiple data providers

Annals of GIS
The problem of data-driven location prediction of individual users is based on an effective mining of travel behaviours and motion patterns. In this sense, a central aspect refers to the use of a relevant amount of historical mobility data, required for ...
Alessandro Crivellari, Yuhui Shi
doaj   +1 more source