Results 121 to 130 of about 2,447,655 (294)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Committee Report on Location of Seminary [PDF]
Report on the committee appointed to recieve propositions on location of seminary.https://digital.kenyon.edu/chase_letters/1525/thumbnail ...
Committee on Seminary Location,
core
Geophysical Research LettersThe Intertropical Convergence Zone (ITCZ) has an annual mean location north of the equator today. The factors determining this location and the evolution to its modern state are actively debated.
Xiaoqing Liu +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Fractional location problems [PDF]
In this paper we analyze some variants of the classical uncapacitated facility location problem with a ratio as an objective function. Using basic concepts and results of fractional programming, we identify a class of one-level fractional location ...
Frenk, J.B.G. +2 more
core
Attenuation of spatial bias with target template variation
Scientific ReportsThis study investigated the impact of target template variation or consistency on attentional bias in location probability learning. Participants conducted a visual search task to find a heterogeneous shape among a homogeneous set of distractors.
Injae Hong, Min-Shik Kim
doaj +1 more source
InformationSpanning two decades (2000–2021), this study delves into how TF-induced momentum shifts differ between regular season and playoff matchups, factoring in home-court advantage and team score status at the time of the call. Analyzing 4196 cases of technical
Gershon Tenenbaum +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Adaptive Adversarial Cross-Domain Segmentation Network for High-Resolution Remote Sensing Images
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingConvolutional neural networks (CNNs) have dominated the field of semantic segmentation of high-resolution remote sensing images. These models often assume that training and test data follow the same distribution.
Jianfen Wei +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source