Results 71 to 80 of about 7,497 (294)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Rytą or ryte? Vakarą or vakare? A corpus analysis of Lithuanian time expressions denoting parts of the day

open access: yesKalbotyra
This paper aims to reveal differences between the competing accusative and locative forms of Lithuanian temporal expressions denoting parts of the day (rytas ‘morning’, diena ‘day’, vakaras ‘evening’, naktis ‘night’).
Nina Kapušová
doaj   +3 more sources

Two ways of encoding location in Greek: Locative applicatives and prepositions

open access: yesGlossa, 2016
Cross-linguistically, oblique theta roles such as location can be encoded by both adpositions and applicative morphemes. In this paper we argue that Standard Modern Greek (SMG), a language that encodes location primarily with prepositions, has a set of ...
Evangelia Daskalaki, Marios Mavrogiorgos
doaj   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In defence of the Discourse Intention feature

open access: yesIsogloss
This paper investigates sentence-focus VS structures in Spanish and Catalan. It is generally assumed that, in Romance languages, a covert element occupies the canonical preverbal position, preventing the subject from moving there.
Núria Barrios Jurado
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The effects of Chinese locative expressions on the directional judgment in two-dimensional layouts

open access: yes, 2004
In the experiment we mainly investigated the effects of Chinese locative expressions on the Directional judgment in Two-Dimensional Layouts. The participants were asked to report, by locative expressions, which direction the line point to.
Q. H. Yang, K. Zhang
core  

Temporal/locative inversion in Arabic

open access: yes, 2017
This research scrutinizes the observation that when the thematic subject is extracted (i.e. questioned) in Jordanian Arabic, temporal/locative inversion may occur.
Marwan Jarrah
core   +2 more sources

Filtered in/filtered out: Locative media and social accessibility in urban spaces

open access: yesStudies in Communication Sciences, 2021
Social accessibility involves the capacity of a person to be reached by other people, typically through established social networks. Locative media provide new complications to the issue of social accessibility in urban spaces. They do not connect people
Darryl A. Pieber
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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