Results 71 to 80 of about 209,667 (304)

Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]

open access: yes, 2009
Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
A. Abdelrahman   +45 more
core   +1 more source

Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity [PDF]

open access: yes, 2020
There has been extensive discussion of the Replication Crisis in many fields, including genome-wide association studies
Cheng, Riyan   +7 more
core   +2 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

open access: yesAdvanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin   +18 more
wiley   +1 more source

Phase-Dependent Response to Afferent Stimulation During Fictive Locomotion: A Computational Modeling Study

open access: yesFrontiers in Neuroscience, 2019
Central pattern generators (CPGs) in the spinal cord generate rhythmic neural activity and control locomotion in vertebrates. These CPGs operate under the control of sensory feedback that affects the generated locomotor pattern and adapt it to the animal'
Soichiro Fujiki   +5 more
doaj   +1 more source

Neuronal Control of Swimming Behavior: Comparison of Vertebrate and Invertebrate Model Systems [PDF]

open access: yes, 2011
Swimming movements in the leech and lamprey are highly analogous, and lack homology. Thus, similarities in mechanisms must arise from convergent evolution rather than from common ancestry.
Buchanan, James T.   +3 more
core   +2 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim   +4 more
wiley   +1 more source

Potential impact of a presumed increase in the biting activity of dengue-virus-infected Aedes aegypti (Diptera: Culicidae) females on virus transmission dynamics

open access: yesMemorias do Instituto Oswaldo Cruz, 2011
Recently, we showed that infection with dengue virus increases the locomotor activity of Aedes aegypti females. We speculate that the observed increased locomotor activity could potentially increase the chances of finding a suitable host and, as a ...
Paula Mendes Luz   +6 more
doaj   +1 more source

Antazoline Hydrochloride, Tripelennamine Hydrochloride and Locomotor Activity

open access: yesJournal of Pharmacy and Pharmacology, 1954
Summary Tripelennamine hydrochloride and antazoline hydrochloride were administered orally and subcutaneously, in amounts of from 1 mg./kg. body weight up to lethal doses, to albino rats assembled in Wahmann vertically-revolving drums for the recording of locomotor activity.
J A, BAIRD, E M, BOYD
openaire   +2 more sources

Soft Neural Interfaces for Circuit‐Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models

open access: yesAdvanced Healthcare Materials, EarlyView.
ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee   +10 more
wiley   +1 more source

Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study

open access: yesHeliyon
Purpose: — Cocaine use disorder (CUD) is a complex disease. Several studies have shown the efficacy of multitarget drugs used to treat CUD. Here we compare the efficacy of mirtazapine (MIR), pindolol (PIN), fluoxetine (FLX), risperidone (RIS), trazodone (
Susana Barbosa-Méndez   +1 more
doaj   +1 more source

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