Results 81 to 90 of about 1,823,579 (281)
PROBLEM OF LOCUS RESOLVED BY THE THEORY OF MECHANISMS [PDF]
Fiabilitate şi Durabilitate, 2018 A problem of locus is transformed into a R-PRP-RPP type mechanism whose synthesis is made. With an initial set of data, is obtained the mechanism in successive positions and the geometric locus, ie two opposite parabola curves.
Mirela CHERCIU, Iulian POPESCU
doaj
On Loops in the Hyperbolic Locus of the Complex H\'enon Map and Their Monodromies
, 2007 We prove John Hubbard's conjecture on the topological complexity of the hyperbolic horseshoe locus of the complex H\'enon map. Indeed, we show that there exist several non-trivial loops in the locus which generate infinitely many mutually different ...
Arai, Zin
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Journal of the Scholarship of Teaching and Learning, 2014 Theoretical models were tested using structural equation modeling to evaluate the interrelations among cognitive motivational variables and academic achievement using a sample of 128 predominately Hispanic pre-service teachers enrolled in two ...
Felicia Castro-Villarreal +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
, 2008 We study the bifurcation loci of quadratic (and unicritical) polynomials and exponential maps. We outline a proof that the exponential bifurcation locus is connected; this is an analog to Douady and Hubbard's celebrated theorem that (the boundary of) the
Rempe, Lasse, Schleicher, Dierk
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source