Results 1 to 10 of about 168 (168)
A genetic locus for paranoia [PDF]
Biology Letters, 2018 The psychological effects of brain-expressed imprinted genes in humans are virtually unknown. Prader–Willi syndrome (PWS) is a neurogenetic condition mediated by genomic imprinting, which involves high rates of psychosis characterized by hallucinations and paranoia, as well as autism.
Bernard Crespi +3 more
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Genetic Elements at the Alpha-Synuclein Locus
Frontiers in Neuroscience, 2022 Genome-wide association studies have consistently shown that the alpha-synuclein locus is significantly associated with Parkinson’s disease. The mechanism by which this locus modulates the disease pathology and etiology remains largely under-investigated.
Jordan Prahl, Gerhard A. Coetzee
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Genetic variability at the PARK16 locus [PDF]
European Journal of Human Genetics, 2010 Parkinson's disease (PD) is a complex neurodegenerative disease which is clinically heterogeneous and pathologically consists of loss of dopaminergic neurons in the substantia nigra and intracytoplasmic neuronal inclusions containing alpha-synuclein aggregations known as Lewy bodies.
Tamas Revesz +7 more
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Genetic Imprinting: Conflict at the Callipyge Locus [PDF]
Current Biology, 2005 The imprinted Dlk1-Gtl2 region of the mammalian genome - which in sheep encompasses the Callipyge locus, known for its unusual mode of inheritance - encodes a number of maternally expressed miRNAs. Five of these miRNAs, hosted by the antisense transcript antiPeg11, have now been shown to target degradation of the paternally expressed Peg11 mRNA by an ...
Annabelle Lewis, Lisa Redrup
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Genetic diversity at the HUMTHO1 locus
Annals of Human Biology, 1998 A World-wide population genetic study on the highly polymorphic DNA locus HUMTHO1, was performed using data collected from 48 studies. Also this study reports new allele frequency data of a Punjabi population (n = 125) from North India. This population is in Hardy-Weinberg equilibrium with 77.6% heterozygosity and power of exclusion at 0.538.
P. Gill +2 more
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Reinforcement of genetic coherence in a two-locus model [PDF]
BMC Evolutionary Biology, 2001 In order to maintain populations as units of reproduction and thus enable anagenetic evolution, genetic factors must exist which prevent continuing reproductive separation or enhance reproductive contact. This evolutionary principle is called genetic coherence and it marks the often ignored counterpart of cladistic evolution.
Gregorius, Hans-Rolf, Steiner, Wilfried
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Genetic variation in the porcine myogenin gene locus [PDF]
Mammalian Genome, 1997 ISSN:1432 ...
Soumillion, A. +4 more
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GENETIC CHANGE IN MUTATIONS AT THE T/t-LOCUS IN THE MOUSE [PDF]
Genetics, 1976 ABSTRACT Recessive lethal or semilethal alleles at the T/t locus in the mouse generate new t-variants, with characteristics different from the parent allele at a rate of about 10-3. Almost invariably the variant chromosome carries marker genes derived from the opposite parental chromosome.
Bennett, D, Dunn, L C, Artzt, K
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THE LOCUS OF EVOLUTION: EVO DEVO AND THE GENETICS OF ADAPTATION [PDF]
Evolution, 2007 An important tenet of evolutionary developmental biology ("evo devo") is that adaptive mutations affecting morphology are more likely to occur in the cis-regulatory regions than in the protein-coding regions of genes. This argument rests on two claims: (1) the modular nature of cis-regulatory elements largely frees them from deleterious pleiotropic ...
Hoekstra, Hopi, Coyne, Jerry A.
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Genetic regulation of the intercellular adhesion locus in staphylococci [PDF]
Frontiers in Cellular and Infection Microbiology, 2012 The formation of biofilms by Staphylococcus aureus and Staphylococcus epidermidis is an important aspect of many staphylococcal infections, most notably endocarditis, osteomyelitis and infections associated with indwelling medical devices. The major constituents of staphylococcal biofilms are polysaccharides, such as poly N-acetyl glucosamine (PIA/PNAG)
David Cue, Chia Y. Lee, Mei G. Lei
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