Results 1 to 10 of about 259,248 (266)

Allele interaction--single locus genetics meets regulatory biology. [PDF]

PLoS ONE, 2010
BACKGROUND: Since the dawn of genetics, additive and dominant gene action in diploids have been defined by comparison of heterozygote and homozygote phenotypes.
Arne B Gjuvsland, Erik Plahte, Tormod Adnøy, Stig W Omholt   +3 more
doaj   +4 more sources

Performance characteristics of the boson rapid SARS–cov–2 antigen test card vs RT–PCR: Cross–reactivity and emerging variants

Heliyon, 2023
Background: SARS–CoV–2 virus has undergone several mutations on its genome, since the onset of the pandemic. Multiple variants of concern (VOC) have emerged including Alpha, Beta, Gamma, and Delta with the more recent one being the Omicron (B.1.1.529 ...
Michail Leventopoulos, Vassiliki Michou, Chrysoula Kyprianidou, Christos Meristoudis, Nikolaos George Manias, Harilaos Panagiotis Kavvadas, Dimitris Nikolopoulos, Vassilis Tsilivakos, Georgios Georgoulias   +8 more
doaj   +1 more source

Lack of variation at phosphoglucose isomerase (pgi) in bumblebees: implications for conservation genetics studies. [PDF]

PLoS ONE, 2013
Assessing genetic variation underlying ecologically important traits is increasingly of interest and importance in population and conservation genetics. For some groups generally useful markers exist for examining the relative role of selection and drift
Jonathan S Ellis, Lucy M Turner, Mairi E Knight   +2 more
doaj   +1 more source

A genetic locus for paranoia [PDF]

Biology Letters, 2018
The psychological effects of brain-expressed imprinted genes in humans are virtually unknown. Prader–Willi syndrome (PWS) is a neurogenetic condition mediated by genomic imprinting, which involves high rates of psychosis characterized by hallucinations and paranoia, as well as autism.
Bernard Crespi, Silven Read, Iiro Salminen, Peter Hurd   +3 more
openaire   +2 more sources

Genetic variability at the PARK16 locus [PDF]

European Journal of Human Genetics, 2010
Parkinson's disease (PD) is a complex neurodegenerative disease which is clinically heterogeneous and pathologically consists of loss of dopaminergic neurons in the substantia nigra and intracytoplasmic neuronal inclusions containing alpha-synuclein aggregations known as Lewy bodies.
Arianna, Tucci, Mike A, Nalls, Henry, Houlden, Tamas, Revesz, Andrew B, Singleton, Nicholas W, Wood, John, Hardy, Coro, Paisán-Ruiz   +7 more
openaire   +2 more sources

Generation of AAVS1 integrated doxycycline-inducible CRISPR-Prime Editor human induced pluripotent stem cell line

Stem Cell Research, 2021
Prime editing uses the Cas9 nickase fused to a reverse transcriptase to copy a DNA sequence into a specific locus from a ‘prime editing’ guide RNA (pegRNA), eliminating the need for double-stranded DNA breaks and donor DNA templates.
Nike Bharucha, Jennifer Arthur Ataam, Alexandra A. Gavidia, Ioannis Karakikes   +3 more
doaj   +1 more source

A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk

Scientific Reports, 2022
Genome-wide association studies (GWAS) have identified many common variant loci associated with asthma susceptibility, but few studies investigate the genetics underlying moderate-to-severe asthma risk.
Diana Chang, Julie Hunkapiller, Tushar Bhangale, Jens Reeder, Kiran Mukhyala, Jennifer Tom, Amy Cowgill, Jan Vogel, William F. Forrest, Zia Khan, Amy Stockwell, Mark I. McCarthy, Tracy L. Staton, Julie Olsson, Cecile T. J. Holweg, Dorothy S. Cheung, Hubert Chen, Matthew J. Brauer, Robert R. Graham, Timothy Behrens, Mark S. Wilson, Joseph R. Arron, David F. Choy, Brian L. Yaspan   +23 more
doaj   +1 more source

The Gene Encoding Dihydroflavonol 4-Reductase Is a Candidate for the anthocyaninless Locus of Rapid Cycling Brassica rapa (Fast Plants Type). [PDF]

PLoS ONE, 2016
Rapid cycling Brassica rapa, also known as Wisconsin Fast Plants, are a widely used organism in both K-12 and college science education. They are an excellent system for genetics laboratory instruction because it is very easy to conduct genetic crosses ...
Douglas L Wendell, Anoumid Vaziri, Gurbaksh Shergill   +2 more
doaj   +1 more source

Development and characterization of 16 novel microsatellite markers by Transcriptome sequencing for Angelica dahurica and test for cross-species amplification

BMC Plant Biology, 2020
Background Angelica dahurica (Apiaceae) is an important herb in traditional Chinese medicine. Because of its important medicinal and economic values, its wild resources were over-exploited and increasingly reduced.
Qianqian Liu, Zuyu Lu, Wei He, Fang Li, Wenna Chen, Chan Li, Zhi Chao, Enwei Tian   +7 more
doaj   +1 more source

Genetic Elements at the Alpha-Synuclein Locus

Frontiers in Neuroscience, 2022
Genome-wide association studies have consistently shown that the alpha-synuclein locus is significantly associated with Parkinson’s disease. The mechanism by which this locus modulates the disease pathology and etiology remains largely under-investigated.
Jordan Prahl, Gerhard A. Coetzee
openaire   +3 more sources