Results 1 to 10 of about 911,373 (309)

Allele interaction--single locus genetics meets regulatory biology. [PDF]

PLoS ONE, 2010
BACKGROUND: Since the dawn of genetics, additive and dominant gene action in diploids have been defined by comparison of heterozygote and homozygote phenotypes.
Arne B Gjuvsland, Erik Plahte, Tormod Adnøy, Stig W Omholt   +3 more
doaj   +4 more sources

Genetics and mapping of a new anthracnose resistance locus in Andean common bean Paloma [PDF]

BMC Genomics, 2017
BackgroundThe Andean cultivar Paloma is resistant to Mesoamerican and Andean races of Colletotrichum lindemuthianum, the fungal pathogen that causes the destructive anthracnose disease in common bean. Remarkably, Paloma is resistant to Mesoamerican races
Sandra Aparecida de Lima Castro, Maria Celeste Gonçalves‐Vidigal, Thiago Alexandre Santana Gílio, Giselly Figueiredo Lacanallo, Giseli Valentini, Vanusa da Silva Ramos Martins, Qijian Song, Marta Zulema Galván, Oscar P. Hurtado‐Gonzales, M. A. Pastor‐Corrales   +9 more
openalex   +2 more sources

SNCA locus duplication carriers: from genetics to Parkinson disease phenotypes [PDF]

Human Mutation, 2011
Genomic multiplication of the alpha‐synuclein gene (SNCA) locus is one cause of familial Parkinson disease (PD). We performed detailed genomic, SNCA expression level, clinical, neuropsychological and functional imaging analyses of a parkinsonian kindred ...
Eugénie Mutez, Frédéric Leprêtre, Émilie Le Rhun, Lydie Larvor, Aurélie Duflot, Vincent Mouroux, Jean‐Pierre Kerckaert, Martin Figeac, Kathy Dujardin, A. Destée, Marie‐Christine Chartier‐Harlin   +10 more
openalex   +2 more sources

Performance characteristics of the boson rapid SARS–cov–2 antigen test card vs RT–PCR: Cross–reactivity and emerging variants

Heliyon, 2023
Background: SARS–CoV–2 virus has undergone several mutations on its genome, since the onset of the pandemic. Multiple variants of concern (VOC) have emerged including Alpha, Beta, Gamma, and Delta with the more recent one being the Omicron (B.1.1.529 ...
Michail Leventopoulos, Vassiliki Michou, Chrysoula Kyprianidou, Christos Meristoudis, Nikolaos George Manias, Harilaos Panagiotis Kavvadas, Dimitris Nikolopoulos, Vassilis Tsilivakos, Georgios Georgoulias   +8 more
doaj   +1 more source

The population genetics characteristics of a 90 locus panel of microhaplotypes

Human Genetics, 2021
Single-nucleotide polymorphisms (SNPs) and small genomic regions with multiple SNPs (microhaplotypes, MHs) are rapidly emerging as novel forensic investigative tools to assist in individual identification, kinship analyses, ancestry inference, and ...
A. Pakstis, Neeru Gandotra, W. Speed, M. Murtha, C. Scharfe, K. Kidd   +5 more
semanticscholar   +1 more source

Plasma proteomic associations with genetics and health in the UK Biobank

Nature, 2023
The Pharma Proteomics Project generates the largest open-access plasma proteomics dataset to date, offering insights into trans protein quantitative trait loci across multiple biological domains, and highlighting genetic influences on ligand–receptor ...
B. Sun, Joshua Chiou, M. Traylor, C. Benner, Yi-Hsiang Hsu, Tom G Richardson, P. Surendran, A. Mahajan, Chloe Robins, Steven G. Vasquez-Grinnell, Liping Hou, E. Kvikstad, O. Burren, Jonathan Davitte, Kyle L. Ferber, C. Gillies, Åsa K Hedman, Sile Hu, Tinchi Lin, Rajesh Mikkilineni, Rion K. Pendergrass, Corran Pickering, Bram Prins, Denis Baird, Chia-Yen Chen, Lucas D. Ward, A. Deaton, Samantha Welsh, Carissa M. Willis, Nick Lehner, M. Arnold, Maria A. Wörheide, Karsten Suhre, G. Kastenmüller, A. Sethi, M. Cule, Anil Raj, Hyun Ming Kang, L. Burkitt-Gray, E. Melamud, Mary Helen Black, E. Fauman, J. Howson, Hyun Min Kang, M. McCarthy, P. Nioi, S. Petrovski, Robert A. Scott, Erin N. Smith, S. Szalma, D. Waterworth, L. Mitnaul, J. Szustakowski, Brad Gibson, Melissa R. Miller, Christopher D. Whelan   +55 more
semanticscholar   +1 more source

Lack of variation at phosphoglucose isomerase (pgi) in bumblebees: implications for conservation genetics studies. [PDF]

PLoS ONE, 2013
Assessing genetic variation underlying ecologically important traits is increasingly of interest and importance in population and conservation genetics. For some groups generally useful markers exist for examining the relative role of selection and drift
Jonathan S Ellis, Lucy M Turner, Mairi E Knight   +2 more
doaj   +1 more source

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

Nature Immunology, 2023
Here the authors identify genetic effectors of the level of inflammation-related plasma proteins and use Mendelian randomization to identify proteins that contribute to immune-mediated disease risk.
Jinghua Zhao, D. Stacey, N. Eriksson, E. Macdonald-Dunlop, Å. Hedman, A. Kalnapenkis, Stefan Enroth, D. Cozzetto, J. Digby-Bell, J. Marten, L. Folkersen, C. Herder, L. Jonsson, Sarah E. Bergen, C. Gieger, E. Needham, P. Surendran, D. Paul, O. Polašek, B. Thorand, H. Grallert, M. Roden, U. Võsa, T. Esko, C. Hayward, Å. Johansson, U. Gyllensten, N. Powell, O. Hansson, N. Mattsson‐Carlgren, Peter K. Joshi, J. Danesh, L. Padyukov, Lars Klareskog, M. Landén, James F. Wilson, A. Siegbahn, L. Wallentin, A. Mälarstig, A. Butterworth, J. Peters   +40 more
semanticscholar   +1 more source

Generation of AAVS1 integrated doxycycline-inducible CRISPR-Prime Editor human induced pluripotent stem cell line

Stem Cell Research, 2021
Prime editing uses the Cas9 nickase fused to a reverse transcriptase to copy a DNA sequence into a specific locus from a ‘prime editing’ guide RNA (pegRNA), eliminating the need for double-stranded DNA breaks and donor DNA templates.
Nike Bharucha, Jennifer Arthur Ataam, Alexandra A. Gavidia, Ioannis Karakikes   +3 more
doaj   +1 more source

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire

Nature Communications, 2023
Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated.
O. Rodriguez, Yana Safonova, Catherine A. Silver, Kaitlyn M. Shields, William S. Gibson, Justin T. Kos, David Tieri, Hanzhong Ke, K. Jackson, S. Boyd, M. Smith, W. Marasco, C. Watson   +12 more
semanticscholar   +1 more source