Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. [PDF]
, 2019 Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6-11.
23andMe Research Team +99 more
core
Using neutral cline decay to estimate contemporary dispersal: a generic tool and its application to a major crop pathogen [PDF]
, 2013 Dispersal is a key parameter of adaptation, invasion and persistence. Yet standard population genetics inference methods hardly distinguish it from drift and many species cannot be studied by direct mark-recapture methods.
Amil +46 more
core +1 more source
Nature Communications, 2019 Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact.
A. Adeyemo +39 more
semanticscholar +1 more source
PLoS Genetics, 2013 Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD ...
Lavinia Paternoster +20 more
doaj +1 more source
An asymptotic sampling formula for the coalescent with Recombination
, 2010 Ewens sampling formula (ESF) is a one-parameter family of probability distributions with a number of intriguing combinatorial connections. This elegant closed-form formula first arose in biology as the stationary probability distribution of a sample ...
Jenkins, Paul A., Song, Yun S.
core +1 more source
2b-RAD genotyping for population genomic studies of Chagas disease vectors: Rhodnius ecuadoriensis in Ecuador [PDF]
, 2017 Background: Rhodnius ecuadoriensis is the main triatomine vector of Chagas disease, American trypanosomiasis, in Southern Ecuador and Northern Peru.
Andersson, Björn +10 more
core +4 more sources
The TCF7L2 Locus: A Genetic Window Into the Pathogenesis of Type 1 and Type 2 Diabetes
Diabetes Care, 2019 Over the past ∼15 years there has been great progress in our understanding of the genetics of both type 1 diabetes and type 2 diabetes. This has been driven principally by genome-wide association studies (GWAS) in increasingly larger sample sizes, where ...
S. Grant
semanticscholar +1 more source
The genetic basis of resistance and matching-allele interactions of a host-parasite system: The Daphnia magna-Pasteuria ramosa model. [PDF]
PLoS Genetics, 2017 Negative frequency-dependent selection (NFDS) is an evolutionary mechanism suggested to govern host-parasite coevolution and the maintenance of genetic diversity at host resistance loci, such as the vertebrate MHC and R-genes in plants.
Gilberto Bento +5 more
doaj +1 more source
Reinforcement of genetic coherence: a single-locus model
Biosystems, 1997 Genetic coherence and genetic separation are the outcome of evolutionary mechanisms which maintain genetic variation within populations through recombination on the one hand, and which divide this variation via speciation between reproductively (recombinatorically) more or less isolated populations on the other.
Steiner, Wilfried, Gregorius, Hans-Rolf
openaire +4 more sources
Development and characterization of novel microsatellite loci in the native tree frog species, Polypedates braueri and cross-species amplification in the alien species, P. megacephalus, in Taiwan [PDF]
Biodiversity Data JournalPolypedates megacephalus is an alien species first recorded in 2006 in Taiwan. The expanding population of P. megacephalus poses potential threats to the native frog species, especially to the closely-related species P. braueri.
Yuan-Cheng Cheng +2 more
doaj +3 more sources