Results 91 to 100 of about 519,503 (373)
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Using linkage analysis to detect gene-gene interaction by stratifying family data on known disease, or disease-associated, alleles. [PDF]
PLoS ONE, 2014 Detecting gene-gene interaction in complex diseases is a major challenge for common disease genetics. Most interaction detection approaches use disease-marker associations and such methods have low power and unknown reliability in real data. We developed
Barbara Corso, David A Greenberg
doaj +1 more source
A Pattern Discovery-Based Method for Detecting Multi-Locus Genetic Association [PDF]
arXiv, 2007 Methods to effectively detect multi-locus genetic association are becoming increasingly relevant in the genetic dissection of complex trait in humans. Current approaches typically consider a limited number of hypotheses, most of which are related to the effect of a single locus or of a relatively small number of neighboring loci on a chromosomal region.
arxiv
Molecular genetics of coat colour in pigs [PDF]
, 2013 Coat colour in Sus scrofa has been the matter of pioneering genetics studies carried out at the beginning of the last century. Since then, classical genetics studies have assumed that several loci affect this trait in pigs.
Fontanesi L., Russo V.
core
A unifying study of phenotypic and molecular genetic variability in natural populations of Anadenanthera colubrina var. cebil from Yungas and Paranaense biogeographic provinces in Argentina [PDF]
, 2014 Anadenanthera colubrina var. cebil is a native tree species in the South American subtropical forests that is discontinuously distributed. Thirteen quantitative traits and eight nuclear microsatellite loci were examined in individuals from two ...
Barrandeguy, Maria Eugenia +4 more
core +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Principia: An International Journal of Epistemology, 2015 The Modern Evolutionary Synthesis relegated the ontogenetic development to a “black box”. In this article, we argue that the absence of ontogenetic development in the Evolutionary Synthesis was due its strong foundation in transmission genetics.
Leonardo Augusto Luvison Araújo +1 more
doaj
PLoS Genetics, 2013 Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD ...
Lavinia Paternoster +20 more
doaj +1 more source
The pattern of genetic hitchhiking under recurrent mutation [PDF]
arXiv, 2008 Genetic hitchhiking describes evolution at a neutral locus that is linked to a selected locus. If a beneficial allele rises to fixation at the selected locus, a characteristic polymorphism pattern (so-called selective sweep) emerges at the neutral locus.
arxiv
Complex Genetic Interactions in a Quantitative Trait Locus
PLoS Genetics, 2006 Whether in natural populations or between two unrelated members of a species, most phenotypic variation is quantitative. To analyze such quantitative traits, one must first map the underlying quantitative trait loci. Next, and far more difficult, one must identify the quantitative trait genes (QTGs), characterize QTG interactions, and identify the ...
Bradly P. Nicholson +3 more
openaire +5 more sources