Results 101 to 110 of about 260,346 (338)
Molecular Oncology, EarlyView.In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen +13 more
wiley +1 more source
BMC Genomics, 2017 Background Ascomycete Cordyceps species have been using as valued traditional Chinese medicines. Particularly, the fruiting bodies of Cordyceps cicadae (syn. Isaria cicadae) have long been utilized for the treatment of chronic kidney disease.
Yuzhen Lu +9 more
doaj +1 more source
The dissection of expression quantitative trait locus hotspots [PDF]
arXiv, 2015 Studies of the genetic loci that contribute to variation in gene expression frequently identify loci with broad effect on gene expression: expression quantitative trait locus (eQTL) hotspots. We describe a set of exploratory graphical methods as well as a formal likelihood-based test for assessing whether a given hotspot is due to one or multiple ...
arxiv
Molecular Oncology, EarlyView.This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke +12 more
wiley +1 more source
QTL Analysis for Drought Tolerance in Wheat: Present Status and Future Possibilities
Agronomy, 2017 In recent years, with climate change, drought stress has been witnessed in many parts of the world. In many irrigated regions also, shortage of water supply allows only limited irrigation.
Pushpendra Kumar Gupta +2 more
doaj +1 more source
To what extent does genealogical ancestry imply genetic ancestry? [PDF]
arXiv, 2008 Recent statistical and computational analyses have shown that a genealogical most recent common ancestor (MRCA) may have lived in the recent past. However, coalescent-based approaches show that genetic most recent common ancestors for a given non-recombining locus are typically much more ancient.
arxiv
Systems Genetics of Single Nucleotide Polymorphisms at the Drosophila Obp56h Locus [PDF]
, 2021 Sneha S. Mokashi +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
A review on SNP and other types of molecular markers and their use in animal genetics
Genetics Selection Evolution, 2002 During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy
Eggen André +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source