Results 161 to 170 of about 911,373 (309)

Insights into genetics, human biology and disease gleaned from family based genomic studies

Genetics in Medicine, 2019
J. Posey, A. O’Donnell-Luria, Jessica X. Chong, T. Harel, S. Jhangiani, Zeynep Coban Akdemir, S. Buyske, D. Pehlivan, C. Carvalho, S. Baxter, Nara Sobreira, Pengfei Liu, Nan Wu, J. Rosenfeld, Sushant Kumar, D. Avramopoulos, Janson J. White, K. Doheny, P. D. Witmer, C. Boehm, V. Sutton, D. Muzny, E. Boerwinkle, Murat Günel, D. Nickerson, S. Mane, D. MacArthur, R. Gibbs, A. Hamosh, R. Lifton, T. Matise, H. Rehm, M. Gerstein, M. Bamshad, D. Valle, J. Lupski, Centers for Mendelian Genomics   +36 more
semanticscholar   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Molecular genetics of normal and mutant purine nucleoside phosphorylase and mapping a GTP regulatory locus in the mouse

, 1993
Jack P. Jenuth
openalex   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Clade distillation for genome-wide association studies. [PDF]

Genetics
Christ R, Wang X, Aslett LJM, Steinsaltz D, Hall I.   +4 more
europepmc   +1 more source

Genetics of shell ground colour in Helix Aspersa I. colour locus, uniform and their interactions [PDF]

, 1984
R M Albuquerque de Matos
openalex   +1 more source

Genetics of Coronary Artery Disease.

Circulation Research, 2016
R. McPherson, A. Tybjaerg-hansen
semanticscholar   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

The power of genetics in decoding Sjögren's disease: current status and future development. [PDF]

Curr Opin Immunol
Radziszewski M, Tessneer KL, Lessard CJ.
europepmc   +1 more source

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source