Results 11 to 20 of about 911,373 (309)

A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk

Scientific Reports, 2022
Genome-wide association studies (GWAS) have identified many common variant loci associated with asthma susceptibility, but few studies investigate the genetics underlying moderate-to-severe asthma risk.
Diana Chang, Julie Hunkapiller, Tushar Bhangale, Jens Reeder, Kiran Mukhyala, Jennifer Tom, Amy Cowgill, Jan Vogel, William F. Forrest, Zia Khan, Amy Stockwell, Mark I. McCarthy, Tracy L. Staton, Julie Olsson, Cecile T. J. Holweg, Dorothy S. Cheung, Hubert Chen, Matthew J. Brauer, Robert R. Graham, Timothy Behrens, Mark S. Wilson, Joseph R. Arron, David F. Choy, Brian L. Yaspan   +23 more
doaj   +1 more source

The Gene Encoding Dihydroflavonol 4-Reductase Is a Candidate for the anthocyaninless Locus of Rapid Cycling Brassica rapa (Fast Plants Type). [PDF]

PLoS ONE, 2016
Rapid cycling Brassica rapa, also known as Wisconsin Fast Plants, are a widely used organism in both K-12 and college science education. They are an excellent system for genetics laboratory instruction because it is very easy to conduct genetic crosses ...
Douglas L Wendell, Anoumid Vaziri, Gurbaksh Shergill   +2 more
doaj   +1 more source

Development and characterization of 16 novel microsatellite markers by Transcriptome sequencing for Angelica dahurica and test for cross-species amplification

BMC Plant Biology, 2020
Background Angelica dahurica (Apiaceae) is an important herb in traditional Chinese medicine. Because of its important medicinal and economic values, its wild resources were over-exploited and increasingly reduced.
Qianqian Liu, Zuyu Lu, Wei He, Fang Li, Wenna Chen, Chan Li, Zhi Chao, Enwei Tian   +7 more
doaj   +1 more source

Genetics of rheumatoid arthritis

Seminars in Immunopathology, 2022
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints and is generally characterized by persistent pain, tenderness, and destruction of joints.
L. Padyukov
semanticscholar   +1 more source

Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy

Journal of Human Genetics, 2022
Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure leading to mortality. The main locus of ALS is motor neurons.
N. Suzuki, A. Nishiyama, H. Warita, M. Aoki   +3 more
semanticscholar   +1 more source

Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) genetics studies have identified a coding variant within ABI3 gene that increases the risk of developing AD. Recently, we demonstrated that deletion of the Abi3 gene locus dramatically exacerbates AD neuropathology in a ...
Daniel C. Smith, Daniel C. Smith, Daniel C. Smith, Hande Karahan, Hande Karahan, H. R. Sagara Wijeratne, H. R. Sagara Wijeratne, H. R. Sagara Wijeratne, Mamun Al-Amin, Mamun Al-Amin, Brianne McCord, Brianne McCord, Younghye Moon, Younghye Moon, Jungsu Kim, Jungsu Kim, Jungsu Kim   +16 more
doaj   +1 more source

Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation

iScience, 2019
Summary: We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter assays
Casimiro Castillejo-Lopez, Milos Pjanic, Anna Chiara Pirona, Susanne Hetty, Martin Wabitsch, Claes Wadelius, Thomas Quertermous, Erik Arner, Erik Ingelsson   +8 more
doaj   +1 more source

An X-STRs analysis of the Iraqi Sorani Kurds.

PLoS ONE, 2023
A database for the Iraqi Sorani Kurds, specifically focused on the 12 X-short tandem repeat (STR) loci, has been developed to fascilitate forensic and population genetics investigations.
Balnd M Albarzinji, Shams Hadi, Bahez Ismael, Ahmed Barqee, Abdullah Hadi, Hayder Lazim   +5 more
doaj   +1 more source

A molecular quantitative trait locus map for osteoarthritis

Nature Communications, 2021
Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To develop disease-stratifying tools and modifying therapies, we need a better understanding of the molecular basis of the disease in relevant tissue and cell ...
J. Steinberg, L. Southam, T. Roumeliotis, M. J. Clark, R. Jayasuriya, D. Swift, Karan M. Shah, N. Butterfield, R. Brooks, A. McCaskie, J. Bassett, G. Williams, Jyoti S. Choudhary, J. Mark, Wilkinson, E. Zeggini   +15 more
semanticscholar   +1 more source

The SSR Null Allele Problem, and Its Consequences in Pedigree Reconstruction and Population Genetic Studies in Viticulture

Horticulturae, 2022
Null alleles are alleles that are recessive to codominant markers without any effect on the phenotype. In SSR assays, there are several reasons for the lack of amplification at a locus: the primer does not bind well, longer fragments do not amplify due ...
Gizella Jahnke, József Smidla, Tamás Deák, Róbert Oláh, Barna Árpád Szőke, Diána Ágnes Nyitrainé Sárdy   +5 more
doaj   +1 more source