Results 11 to 20 of about 540,367 (350)
Genetic Elements at the Alpha-Synuclein Locus
Frontiers in Neuroscience, 2022 Genome-wide association studies have consistently shown that the alpha-synuclein locus is significantly associated with Parkinson’s disease. The mechanism by which this locus modulates the disease pathology and etiology remains largely under-investigated.
Jordan Prahl, Gerhard A. Coetzee
openaire +3 more sources
Genetic Imprinting: Conflict at the Callipyge Locus [PDF]
Current Biology, 2005 The imprinted Dlk1-Gtl2 region of the mammalian genome - which in sheep encompasses the Callipyge locus, known for its unusual mode of inheritance - encodes a number of maternally expressed miRNAs. Five of these miRNAs, hosted by the antisense transcript antiPeg11, have now been shown to target degradation of the paternally expressed Peg11 mRNA by an ...
Lewis, Annabelle, Redrup, Lisa
openaire +2 more sources
Increasing power for voxel-wise genome-wide association studies : the random field theory, least square kernel machines and fast permutation procedures [PDF]
, 2012 Imaging traits are thought to have more direct links to genetic variation than diagnostic measures based on cognitive or clinical assessments and provide a powerful substrate to examine the influence of genetics on human brains. Although imaging genetics
Feng, Jianfeng +4 more
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Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD) genetics studies have identified a coding variant within ABI3 gene that increases the risk of developing AD. Recently, we demonstrated that deletion of the Abi3 gene locus dramatically exacerbates AD neuropathology in a ...
Daniel C. Smith +16 more
doaj +1 more source
Integration of genetic and physical maps of the Primula vulgaris S locus and localization by chromosome in situ hybridization [PDF]
, 2015 •Heteromorphic flower development in Primula is controlled by the S locus. The S locus genes, which control anther position, pistil length and pollen size in pin and thrum flowers, have not yet been characterized.
Altenburg E +20 more
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The effect of recurrent mutations on genetic diversity in a large population of varying size [PDF]
, 2016 Recurrent mutations are a common phenomenon in population genetics. They may be at the origin of the fixation of a new genotype, if they give a phenotypic advantage to the carriers of the new mutation.
Smadi, Charline
core +3 more sources
iScience, 2019 Summary: We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter assays
Casimiro Castillejo-Lopez +8 more
doaj +1 more source
An X-STRs analysis of the Iraqi Sorani Kurds.
PLoS ONE, 2023 A database for the Iraqi Sorani Kurds, specifically focused on the 12 X-short tandem repeat (STR) loci, has been developed to fascilitate forensic and population genetics investigations.
Balnd M Albarzinji +5 more
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Shared genetic contribution of type 2 diabetes and cardiovascular disease: Implications for prognosis and treatment [PDF]
, 2018 Purpose of Review: The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the available evidence and assesses the shared genetic background between T2D and CVD: the causal ...
Strawbridge, Rona J. +1 more
core +1 more source
Horticulturae, 2022 Null alleles are alleles that are recessive to codominant markers without any effect on the phenotype. In SSR assays, there are several reasons for the lack of amplification at a locus: the primer does not bind well, longer fragments do not amplify due ...
Gizella Jahnke +5 more
doaj +1 more source