Results 191 to 200 of about 259,248 (266)

A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniae. [PDF]

PLoS Genet
Maziero M, Juillot D, Mortier-Barrière I, Carballido-Lopez R, Campo N, Genevaux P, Bordes P, Polard P, Bergé M.   +8 more
europepmc   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

A bittersweet symphony: genetic insights into cider apple fruit quality. [PDF]

G3 (Bethesda)
Bouillon P, Zakalik D, Brown M, Krishna Kumar S, Peck G.   +4 more
europepmc   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Differential genome-wide association analysis of schizophrenia and post-traumatic stress disorder identifies opposing effects at the <i>MAPT</i>/<i>CRHR1</i> locus. [PDF]

Front Genet
Cheng ZS.
europepmc   +1 more source

Modulating Two‐Photon Absorption in a Pyrene‐Based MOF Series: An In‐Depth Investigation of Structure–Property Relationships

Advanced Functional Materials, EarlyView.
This study investigates H4TBAPy‐based metal–organic frameworks (MOFs) ‐ NU‐1000, NU‐901, SrTBAPy, and BaTBAPy ‐ for multiphoton absorption (MPA) performance. It observes topology‐dependent variations in the 2PA cross‐section, with BaTBAPy exhibiting the highest activity.
Simon N. Deger, Helmy Pacheco Hernandez, Yang Cui, Hongxing Hao, Vanessa Ramm, David C. Mayer, Khai‐Nghi Truong, Roland A. Fischer, Jürgen Hauer, Mariana Kozlowska, Alexander Pöthig   +10 more
wiley   +1 more source

Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants. [PDF]

Nat Genet
Geller F, Wu X, Lammi V, Abner E, Valliere JT, Nastou K, Burns A, Rasmussen M, Andersson NW, Quinn L, DBDS Genomic Consortium, Aagaard B, Banasik K, Bliddal S, Boding L, Brunak S, Brøns N, Bybjerg-Grauholm J, Christoffersen LAN, Didriksen M, Dinh KM, Erikstrup C, Feldt-Rasmussen U, Grønbæk K, Kaspersen KA, Mikkelsen C, Nielsen CH, Nielsen HS, Nielsen SD, Nissen J, Sequeros CB, Tommerup N, Ullum H, Estonian Biobank Research Team, FinnGen, Spiliopoulos L, Bager P, Hviid A, Sørensen E, Pedersen OB, Lane JM, Lassaunière R, Ollila HM, Ostrowski SR, Feenstra B.   +44 more
europepmc   +1 more source

Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions

Advanced Functional Materials, EarlyView.
This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian, Jingkai Lin, Zhihao Tian, Selusiwe Ncube, Huayang Zhang, Emiliano Cortés, Hongqi Sun, Shaobin Wang   +7 more
wiley   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

gyōza: a Snakemake workflow for modular analysis of deep-mutational scanning data. [PDF]

Genetics
Durand R, Pageau A, Landry CR.
europepmc   +1 more source