Results 281 to 290 of about 540,367 (350)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

A preliminary assessment of population genetic structure of the common vampire bat (<i>Desmodus rotundus</i>) in Colombia. [PDF]

PeerJ
Van de Vuurst P, Cifuentes-Rincon A, Bertke AS, Soler-Tovar D, Reyes-Amaya N, Rodriguez Arévalo F, Cárdenas Hincapié JS, Rivera-Monroy J, Escobar LE, Hallerman E.   +9 more
europepmc   +1 more source

Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo

Advanced Functional Materials, EarlyView.
This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić, Albert Espona‐Noguera, Angela Privat Maldonado, Patrik Matušů, Francesco Tampieri, Maria‐Pau Ginebra, Abraham Lin, Evelien Smits, Annemie Bogaerts, Cristina Canal   +9 more
wiley   +1 more source

Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk. [PDF]

PLoS Genet
Carlson JC, Zhang X, Erdogan-Yildirim Z, Beaty TH, Butali A, Buxó CJ, Gowans LJJ, Hecht JT, Long RE, Moreno L, Murray JC, Orioli IM, Padilla C, Wehby GL, Feingold E, Leslie-Clarkson EJ, Weinberg SM, Marazita ML, Shaffer JR.   +18 more
europepmc   +1 more source

Atomic Size Misfit for Electrocatalytic Small Molecule Activation

Advanced Functional Materials, EarlyView.
This review explores the application and mechanisms of atomic size misfit in catalysis for small molecule activation, focusing on how structural defects and electronic properties can effectively lower the energy barriers of chemical bonds in molecules like H2O, CO2, and N2.
Ping Hong, Changfan Xu, Huaping Zhao, Yong Lei   +3 more
wiley   +1 more source

Exploring MAPT-containing H1 and H2 haplotypes in Parkinson’s disease across diverse populations

Reyes-Pérez P, Hor JW, Toh TS, Sanyaolu AO, Pantazis CB, Leal TP, Yeboah S, Bandres-Ciga S, Morris HR, Makarious MB, Senkevich K, the Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD), the Global Parkinson’s Genetics Program (GP2), Leonard H, Brolin KA.   +14 more
europepmc   +1 more source

Neutral genetic diversity during selective sweeps in nonrecombining populations. [PDF]

Genetics
Kaushik S, Jain K, Johri P.
europepmc   +1 more source

Copper‐based Materials for Photo and Electrocatalytic Process: Advancing Renewable Energy and Environmental Applications

Advanced Functional Materials, EarlyView.
Cu‐based catalysts as a cornerstone in advancing sustainable energy technologies are fully reviewed in this manuscript, highlighting their potential in photo‐ and electrocatalysis. It includes metallic copper, copper oxides, copper sulfides, copper halide perovskites, copper‐based metal–organic frameworks (MOFs), and covalent organic frameworks (COFs),
Jéssica C. de Almeida, Yanjie Wang, Thais A. Rodrigues, Paulo H. H. Nunes, Vagner R. de Mendonça, Paulo H. E. Falsetti, Leticia V. Savazi, Tao He, Alexandra V. Bardakova, Aida V. Rudakova, Jie Tian, Alexei V. Emeline, Osmando F. Lopes, Antonio Otavio T. Patrocínio, Jia Hong Pan, Caue Ribeiro, Detlef W. Bahnemann   +16 more
wiley   +1 more source

Familial 22q11.2 Duplication/Deletion Syndrome: A Testament to the Long-Standing Clinical Utility of FISH. [PDF]

Clin Case Rep
Bryant LM, Hokanson R, Hickey SE, Zapanta B, Hunter J, Reshmi SC.   +5 more
europepmc   +1 more source