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Genetic diversity at the HUMTHO1 locus
Annals of Human Biology, 1998 A World-wide population genetic study on the highly polymorphic DNA locus HUMTHO1, was performed using data collected from 48 studies. Also this study reports new allele frequency data of a Punjabi population (n = 125) from North India. This population is in Hardy-Weinberg equilibrium with 77.6% heterozygosity and power of exclusion at 0.538.
E C, Watson, P, Gill, S S, Mastana
openaire +2 more sources
The nk model and population genetics [PDF]
, 2005 The nk model of fitness interactions is examined. This model has been used by previous authors to investigate the effects of fitness epistasis on substitution dynamics in molecular evolution, and to make broader claims about the importance of epistasis ...
Barton +54 more
core +2 more sources
Adaptive topographies and equilibrium selection in an evolutionary game. [PDF]
PLoS ONE, 2015 It has long been known in the field of population genetics that adaptive topographies, in which population equilibria maximise mean population fitness for a trait regardless of its genetic bases, do not exist.
Hinke M Osinga, James A R Marshall
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Genetic Analysis of Mitochondrial Sorting from the MSC3 Mosaic Mutant of Cucumber
Journal of the American Society for Horticultural Science, 2021 Cucumber (Cucumis sativus) plants regenerated from cell cultures occasionally possess mosaic (MSC) phenotypes on cotyledons and leaves. Lines MSC3 and MSC16 have distinct MSC phenotypes and originated from plants regenerated from different cell-culture ...
Lyle T. Wallace, Michael J. Havey
doaj +1 more source
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]
, 2017 Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC +34 more
core +1 more source
The Population Genetic Signature of Polygenic Local Adaptation [PDF]
, 2014 Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals.
Berg, Jeremy J., Coop, Graham
core +8 more sources
Mutation analysis of 21 autosomal short tandem repeats in Han population from Hunan, China
Annals of Human Biology, 2019 Background: Short tandem repeats (STRs) are powerful genetic markers widely used in human genetics. Population data and locus-specific mutation rates of STRs are crucial for the evaluation and interpretation of genetic evidence in forensic and population
Wei Xu +7 more
doaj +1 more source
Journal of Lipid Research, 2012 A higher incidence of coronary artery disease is associated with a lower level of HDL-cholesterol. We searched for genetic loci influencing HDL-cholesterol in F2 mice from a cross between MRL/MpJ and SM/J mice.
Magalie S. Leduc +6 more
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lociNGS: a lightweight alternative for assessing suitability of next-generation loci for evolutionary analysis. [PDF]
PLoS ONE, 2012 Genomic enrichment methods and next-generation sequencing produce uneven coverage for the portions of the genome (the loci) they target; this information is essential for ascertaining the suitability of each locus for further analysis.
Sarah M Hird
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Using Gene Editing to Establish a Safeguard System for Pluripotent Stem-Cell-Based Therapies
iScience, 2019 Summary: A major challenge in using human pluripotent stem cells (hPSCs) in therapy is the risk of teratoma formation due to contaminating undifferentiated stem cells. We used CRISPR-Cas9 for in-frame insertion of a suicide gene, iC9, into the endogenous
Youjun Wu +5 more
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