Results 31 to 40 of about 1,170,009 (287)

Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation

open access: yesiScience, 2019
Summary: We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter assays
Casimiro Castillejo-Lopez   +8 more
doaj   +1 more source

The SSR Null Allele Problem, and Its Consequences in Pedigree Reconstruction and Population Genetic Studies in Viticulture

open access: yesHorticulturae, 2022
Null alleles are alleles that are recessive to codominant markers without any effect on the phenotype. In SSR assays, there are several reasons for the lack of amplification at a locus: the primer does not bind well, longer fragments do not amplify due ...
Gizella Jahnke   +5 more
doaj   +1 more source

Including copy number variation in association studies to predict genotypic values [PDF]

open access: yes, 2010
The objective of this study was to investigate, both empirically and deterministically, the ability to explain genetic variation resulting from a copy number polymorphism (CNP) by including the CNP, either by its genotype or by a continuous derivation ...
Calus, M.P.L.   +2 more
core   +2 more sources

Genetic diversity at the HUMTHO1 locus

open access: yesAnnals of Human Biology, 1998
A World-wide population genetic study on the highly polymorphic DNA locus HUMTHO1, was performed using data collected from 48 studies. Also this study reports new allele frequency data of a Punjabi population (n = 125) from North India. This population is in Hardy-Weinberg equilibrium with 77.6% heterozygosity and power of exclusion at 0.538.
P. Gill   +2 more
openaire   +3 more sources

Reinforcement of genetic coherence in a two-locus model [PDF]

open access: yesBMC Evolutionary Biology, 2001
In order to maintain populations as units of reproduction and thus enable anagenetic evolution, genetic factors must exist which prevent continuing reproductive separation or enhance reproductive contact. This evolutionary principle is called genetic coherence and it marks the often ignored counterpart of cladistic evolution.
Gregorius, Hans-Rolf, Steiner, Wilfried
openaire   +5 more sources

Adaptive topographies and equilibrium selection in an evolutionary game. [PDF]

open access: yesPLoS ONE, 2015
It has long been known in the field of population genetics that adaptive topographies, in which population equilibria maximise mean population fitness for a trait regardless of its genetic bases, do not exist.
Hinke M Osinga, James A R Marshall
doaj   +1 more source

Genetic Analysis of Mitochondrial Sorting from the MSC3 Mosaic Mutant of Cucumber

open access: yesJournal of the American Society for Horticultural Science, 2021
Cucumber (Cucumis sativus) plants regenerated from cell cultures occasionally possess mosaic (MSC) phenotypes on cotyledons and leaves. Lines MSC3 and MSC16 have distinct MSC phenotypes and originated from plants regenerated from different cell-culture ...
Lyle T. Wallace, Michael J. Havey
doaj   +1 more source

lociNGS: a lightweight alternative for assessing suitability of next-generation loci for evolutionary analysis. [PDF]

open access: yesPLoS ONE, 2012
Genomic enrichment methods and next-generation sequencing produce uneven coverage for the portions of the genome (the loci) they target; this information is essential for ascertaining the suitability of each locus for further analysis.
Sarah M Hird
doaj   +1 more source

Mutation analysis of 21 autosomal short tandem repeats in Han population from Hunan, China

open access: yesAnnals of Human Biology, 2019
Background: Short tandem repeats (STRs) are powerful genetic markers widely used in human genetics. Population data and locus-specific mutation rates of STRs are crucial for the evaluation and interpretation of genetic evidence in forensic and population
Wei Xu   +7 more
doaj   +1 more source

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