Results 31 to 40 of about 519,503 (373)
The best of both worlds: Combining population genetic and quantitative genetic models [PDF]
, 2021 Numerous traits under migration-selection balance are shown to exhibit complex patterns of genetic architecture with large variance in effect sizes. However, the conditions under which such genetic architectures are stable have yet to be investigated, because studying the influence of a large number of small allelic effects on the maintenance of ...
arxiv +1 more source
THE LOCUS OF EVOLUTION: EVO DEVO AND THE GENETICS OF ADAPTATION [PDF]
Evolution, 2007 An important tenet of evolutionary developmental biology ("evo devo") is that adaptive mutations affecting morphology are more likely to occur in the cis-regulatory regions than in the protein-coding regions of genes. This argument rests on two claims: (1) the modular nature of cis-regulatory elements largely frees them from deleterious pleiotropic ...
Hoekstra, Hopi E., Coyne, Jerry A.
openaire +3 more sources
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]
, 2017 Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC +34 more
core +1 more source
BMC Genetics, 2020 Background Aedes aegypti is the primary vector of arthropod-borne viruses and one of the most widespread and invasive mosquito species. Due to the lack of efficient specific drugs or vaccination strategies, vector population control methods, such as the ...
Antonios A. Augustinos +5 more
doaj +1 more source
Frontiers in Plant Science, 2023 Garden roses are an economically important horticultural crop worldwide, and two major fungal pathogens, black spot (Diplocarpon rosae F.A. Wolf) and cercospora leaf spot of rose (Rosisphaerella rosicola Pass.), affect both the health and ornamental ...
Jeekin Lau +6 more
doaj +1 more source
Coalescence in a random background [PDF]
Annals of Probability 2004, Vol. 14, No. 2, 754-785, 2004 We consider a single genetic locus which carries two alleles, labelled P and Q. This locus experiences selection and mutation. It is linked to a second neutral locus with recombination rate r. If r=0, this reduces to the study of a single selected locus.
arxiv +1 more source
Genetic regulation of the intercellular adhesion locus in staphylococci [PDF]
Frontiers in Cellular and Infection Microbiology, 2012 The formation of biofilms by Staphylococcus aureus and Staphylococcus epidermidis is an important aspect of many staphylococcal infections, most notably endocarditis, osteomyelitis and infections associated with indwelling medical devices. The major constituents of staphylococcal biofilms are polysaccharides, such as poly N-acetyl glucosamine (PIA/PNAG)
David Cue, Chia Y. Lee, Mei G. Lei
openaire +4 more sources
npj Genomic Medicine, 2022 We developed an integrative transcriptomic, evolutionary, and causal inference framework for a deep region-level analysis, which integrates several published approaches and a new summary-statistics-based methodology.
Dan Zhou, Eric R. Gamazon
doaj +1 more source
Linkage disequilibrium under recurrent bottlenecks [PDF]
Genetics 190, 217 (2012), 2011 Understanding patterns of selectively neutral genetic variation is essential in order to model deviations from neutrality, caused for example by different forms of selection. Best understood is neutral genetic variation at a single locus, but additional insights can be gained by investigating genetic variation at multiple loci.
arxiv +1 more source
The effect of recurrent mutations on genetic diversity in a large population of varying size [PDF]
, 2016 Recurrent mutations are a common phenomenon in population genetics. They may be at the origin of the fixation of a new genotype, if they give a phenotypic advantage to the carriers of the new mutation.
Smadi, Charline
core +3 more sources