Results 51 to 60 of about 911,373 (309)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Molecular genetics is on the guard of the law

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Molecular genetics is one of the key tools of modern medicine. With its help, scientists can study the structure and function of DNA, decode genetic codes, and develop new treatments.
L. I. Kucherenko, I. V. Pavliuk, O. V. Khromylova   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Alzheimer’s Disease Risk Variants Interact with Amyloid-Beta to Modulate Monocyte Function

Cells
While genetics implicate a central role for dysregulated innate immunity in Alzheimer’s disease (AD), the contributions of peripheral myeloid cells, such as monocytes, have been largely overlooked in favor of microglia.
Zena K. Chatila, Elizabeth M. Bradshaw
doaj   +1 more source

The Genetic Determinism of Biochemical Systems Polymorphous From the Blood Serum in Pigs

Scientific Papers Animal Science and Biotechnologies, 2023
The study of genetic markers and identification of new markers make the subject of an increasing number of research projects in various fields such as genetics of immunology, biochemical genetics, molecular genetics, quantitative genetics and the genetic
Nicoleta Işfan, Dana Popa, Razvan Popa, Carmen Nicolae, Monica Marin, Marius Maftei   +5 more
doaj  

Locus of Control and Obesity

Frontiers in Endocrinology, 2014
In the developed world, the hazards associated with obesity have largely outstripped the risk of starvation. Obesity remains a difficult public health issue to address, due in large part to the many disciplines involved.
Florence eNeymotin, Louis R Nemzer
doaj   +1 more source

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

Nature Communications, 2019
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact.
A. Adeyemo, N. Zaghloul, Guanjie Chen, A. Doumatey, C. C. Leitch, Timothy L. Hostelley, Jessica E. Nesmith, Jie Zhou, A. Bentley, D. Shriner, O. Fasanmade, G. Okafor, B. Eghan, K. Agyenim‐Boateng, S. Chandrasekharappa, J. Adeleye, W. Balogun, S. Owusu, A. Amoah, J. Acheampong, Thomas Johnson, J. Oli, C. Adebamowo, Ji Meng Fraser Tommy Cristina Elizabeth H. Manjinder Chen Sun Pirie Carstensen Pomilla Young Sandhu Mor, Ji Chen, Meng Sun, F. Pirie, T. Carstensen, C. Pomilla, E. Young, M. Sandhu, A. Morris, I. Barroso, M. McCarthy, A. Mahajan, E. Wheeler, A. Motala, F. Collins, G. Dunston, C. Rotimi   +39 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source