Results 51 to 60 of about 519,503 (373)

The Genetics of Human Schistosomiasis Infection Intensity and Liver Disease: A Review

Frontiers in Immunology, 2021
Schistosomiasis remains the fourth most prevalent parasitic disease affecting over 200 million people worldwide. Control efforts have focussed on the disruption of the life cycle targeting the parasite, vector and human host.
Estelle M. Mewamba, Oscar A. Nyangiri, Harry A. Noyes, Moses Egesa, Moses Egesa, Enock Matovu, Gustave Simo   +6 more
doaj   +1 more source

A dual process for the coupled Wright-Fisher diffusion [PDF]

Journal of Mathematical Biology 82, 6 (2021), 2019
The coupled Wright-Fisher diffusion is a multi-dimensional Wright-Fisher diffusion for multi-locus and multi-allelic genetic frequencies, expressed as the strong solution to a system of stochastic differential equations that are coupled in the drift, where the pairwise interaction among loci is modelled by an inter-locus selection.
arxiv   +1 more source

Genetic Incompatibilities Between Mitochondria and Nuclear Genes: Effect on Gene Flow and Speciation

Frontiers in Genetics, 2019
The process of speciation is, according to the biological species concept, the reduction in gene flow between genetically diverging populations. Most of the previous theoretical studies analyzed the effect of nuclear genetic incompatibilities on gene ...
Arndt Telschow, Jürgen Gadau, John H. Werren, Yutaka Kobayashi   +3 more
doaj   +1 more source

Genomic survey sequencing, development and characterization of single- and multi-locus genomic SSR markers of Elymus sibiricus L

BMC Plant Biology, 2021
Background Siberian wildrye (Elymus sibiricus L.) attracts considerable interest for grassland establishment and pasture recovery in the Qinghai-Tibet Plateau (QTP) due to its excellence in strong stress tolerance, high nutritional value and ease to ...
Yi Xiong, Xiong Lei, Shiqie Bai, Yanli Xiong, Wenhui Liu, Wendan Wu, Qingqing Yu, Zhixiao Dong, Jian Yang, Xiao Ma   +9 more
doaj   +1 more source

The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]

, 2013
We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified ...
arxiv   +1 more source

Fast and cost-effective mining of microsatellite markers using NGS technology: an example of a Korean water deer Hydropotes inermis argyropus. [PDF]

PLoS ONE, 2011
BACKGROUND: Microsatellites, a special class of repetitive DNA sequence, have become one of the most popular genetic markers for population/conservation genetic studies.
Jeong-Nam Yu, Changman Won, Jumin Jun, Youngwoon Lim, Myounghai Kwak   +4 more
doaj   +1 more source

Including copy number variation in association studies to predict genotypic values [PDF]

, 2010
The objective of this study was to investigate, both empirically and deterministically, the ability to explain genetic variation resulting from a copy number polymorphism (CNP) by including the CNP, either by its genotype or by a continuous derivation ...
Calus, M.P.L., Haley, C.S., Koning, de, D.J.   +2 more
core   +2 more sources

The evolution of genetic variability at the LRRK2 locus

Genes
Abstract Leucine-rich repeat kinase 2 (LRRK2) c.6055G>A (p.G2019S) is a frequent cause of Parkinson’s disease (PD) accounting for >30% of Tunisian Arab-Berber patients. LRRK2 is widely expressed in the immune system and its kinase activity confers a survival advantage from infection in animal models.
Dylan T. Guenther, Jordan Follett, Rim Amouri, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer   +5 more
openaire   +2 more sources

Searching for interacting QTL in related populations of an outbreeding species [PDF]

, 2009
Many important crop species are outbreeding. In outbreeding species the search for genes affecting traits is complicated by the fact that in a single cross up to four alleles may be present at each locus.
Bink, M.C.A.M., Boer, M.P., Jansen, J., Weg, W.E., van de   +3 more
core   +2 more sources

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source