Results 61 to 70 of about 911,373 (309)

The TCF7L2 Locus: A Genetic Window Into the Pathogenesis of Type 1 and Type 2 Diabetes

Diabetes Care, 2019
Over the past ∼15 years there has been great progress in our understanding of the genetics of both type 1 diabetes and type 2 diabetes. This has been driven principally by genome-wide association studies (GWAS) in increasingly larger sample sizes, where ...
S. Grant
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Por que o desenvolvimento ontogenético foi tratado como uma “caixa preta” na síntese moderna da evolução?

Principia: An International Journal of Epistemology, 2015
The Modern Evolutionary Synthesis relegated the ontogenetic development to a “black box”. In this article, we argue that the absence of ontogenetic development in the Evolutionary Synthesis was due its strong foundation in transmission genetics.
Leonardo Augusto Luvison Araújo, Aldo Mellender de Araújo   +1 more
doaj  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Deciphering Resistance to Root-Knot Nematodes in Prunus for Rootstock Breeding: Sources, Genetics and Characterization of the Ma Locus [PDF]

, 2021
Daniel Esmenjaud
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The genetic basis of resistance and matching-allele interactions of a host-parasite system: The Daphnia magna-Pasteuria ramosa model. [PDF]

PLoS Genetics, 2017
Negative frequency-dependent selection (NFDS) is an evolutionary mechanism suggested to govern host-parasite coevolution and the maintenance of genetic diversity at host resistance loci, such as the vertebrate MHC and R-genes in plants.
Gilberto Bento, Jarkko Routtu, Peter D Fields, Yann Bourgeois, Louis Du Pasquier, Dieter Ebert   +5 more
doaj   +1 more source

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium

PLoS Genetics, 2017
Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but few have been identified through screening of the African ...
M. Ng, M. Graff, Yingchang Lu, A. Justice, Poorva Mudgal, Ching‐Ti Liu, K. Young, L. Yanek, M. Feitosa, M. Wojczynski, K. Rand, J. Brody, B. Cade, B. Cade, Latchezar Dimitrov, Qing Duan, Xiuqing Guo, L. Lange, M. Nalls, H. Okut, S. Tajuddin, B. Tayo, S. Vedantam, S. Vedantam, J. Bradfield, Guanjie Chen, Wei-Min Chen, A. Chesi, M. Irvin, Badri K. Padhukasahasram, Jennifer A. Smith, W. Zheng, M. Allison, C. Ambrosone, E. Bandera, Traci M. Bartz, S. Berndt, L. Bernstein, W. Blot, E. Bottinger, J. Carpten, S. Chanock, Y. Chen, D. Conti, R. Cooper, M. Fornage, B. Freedman, M. Garcia, P. Goodman, Yu-Han H. Hsu, Yu-Han H. Hsu, Yu-Han H. Hsu, Jennifer J. Hu, C. Huff, S. Ingles, E. John, E. John, R. Kittles, E. Klein, Jin Li, B. McKnight, Uma Nayak, B. Nemesure, A. Ogunniyi, A. Olshan, M. Press, Rebecca R. Rohde, B. Rybicki, B. Salako, M. Sanderson, Y. Shao, D. Siscovick, J. Stanford, J. Stanford, V. Stevens, Alexander Stram, S. Strom, Dhananjay Vaidya, Dhananjay Vaidya, J. Witte, Jie Yao, Xiaofeng Zhu, R. Ziegler, A. Zonderman, A. Adeyemo, S. Ambs, M. Cushman, J. Faul, H. Hakonarson, H. Hakonarson, A. Levin, K. Nathanson, E. Ware, D. Weir, Wei Zhao, Degui Zhi, D. Arnett, S. Grant, S. Kardia, Olufunmilayo I Oloapde, D. Rao, C. Rotimi, M. Sale, L. Williams, B. Zemel, B. Zemel, D. Becker, I. Borecki, I. Borecki, M. Evans, T. Harris, J. Hirschhorn, J. Hirschhorn, J. Hirschhorn, Yun Li, Sanjay R. Patel, B. Psaty, B. Psaty, J. Rotter, James G. Wilson, D. Bowden, L. Cupples, L. Cupples, C. Haiman, R. Loos, K. North   +125 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source