Results 71 to 80 of about 911,373 (309)
PLoS Genetics, 2013 Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD ...
Lavinia Paternoster +20 more
doaj +1 more source
Phylogenetic divergence and population genetics of the hydrothermal vent annelid genus Hesiolyra along the East Pacific Rise: Reappraisal using multi‐locus data [PDF]
, 2022 Leyi Xi +7 more
openalex +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A forward genetics approach integrating genome‐wide association study and expression quantitative trait locus mapping to dissect leaf development in maize (Zea mays) [PDF]
, 2021 Mara Miculan +6 more
openalex +1 more source
Nature Genetics, 2012 Population structure causes genome-wide linkage disequilibrium between unlinked loci, leading to statistical confounding in genome-wide association studies.
V. Segura +6 more
semanticscholar +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Development and characterization of novel microsatellite loci in the native tree frog species, Polypedates braueri and cross-species amplification in the alien species, P. megacephalus, in Taiwan [PDF]
Biodiversity Data JournalPolypedates megacephalus is an alien species first recorded in 2006 in Taiwan. The expanding population of P. megacephalus poses potential threats to the native frog species, especially to the closely-related species P. braueri.
Yuan-Cheng Cheng +2 more
doaj +3 more sources
The Genetics and Epigenetics of Facioscapulohumeral Muscular Dystrophy.
Annual review of genomics and human genetics (Print), 2019 Facioscapulohumeral muscular dystrophy (FSHD), a progressive myopathy that afflicts individuals of all ages, provides a powerful model of the complex interplay between genetic and epigenetic mechanisms of chromatin regulation.
C. Himeda, Peter L Jones
semanticscholar +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source