Results 81 to 90 of about 911,373 (309)
Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane +9 morewiley +1 more sourceMulti-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK, GRB14, and KIAA0825 as novel risk loci for Alzheimer disease: the Alzheimer Disease Genetics Consortium
medRxiv, 2023 F. Rajabli, Penelope H. Benchek, G. Tosto, Nicholas A. Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, K. Hamilton-Nelson, Nicholas R. Wheeler, Yi Zhao, John J Farrell, M. Grunin, Y. Leung, Pavel P. Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse Mez, Ellen L Palmer, Jagan A. Pillai, Richard Sherva, Yeunjoo E. Song, Xiaoling Zhang, T. Iqbal, Omkar Pathak, O. Valladares, A. Kuzma, E. Abner, P. Adams, Alyssa Aguirre, Marilyn S. Albert, R. Albin, M. Allen, Lisa Alvarez, L. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig S. Atwood, Gayle Ayres, Clinton T. Baldwin, Robert C. Barber, Lisa L. Barnes, S. Barral, T. Beach, James T. Becker, G. Beecham, D. Beekly, B. Benitez, David A. Bennett, J. Bertelson, Thomas D. Bird, Deborah Blacker, B. Boeve, J. Bowen, A. Boxer, J. Brewer, James R. Burke, Jeffrey M. Burns, J. Buxbaum, Nigel J. Cairns, L. Cantwell, Chuanhai Cao, Christopher S. Carlson, C. Carlsson, R. Carney, M. Carrasquillo, S. Chasse, M. Chesselet, N. Chin, H. Chui, Jaeyoon Chung, Suzanne Craft, Paul K. Crane, D. Cribbs, E. Crocco, C. Cruchaga, M. Cuccaro, M. Cullum, E. Darby, Barbara Davis, P. D. De Jager, C. DeCarli, J. Detoledo, M. Dick, Dennis W. Dickson, B. Dombroski, R. Doody, R. Duara, Nilufer Ertekin-Taner, Denis A. Evans, K. Faber, T. Fairchild, K. Fallon, D. Fardo, Martin R. Farlow, Victoria Fernandez-Hernandez, S. Ferris, T. Foroud, Matthew P. Frosch, B. Fulton-Howard, D. Galasko, Adriana Gamboa, M. Gearing, D. Geschwind, B. Ghetti, John R. Gilbert, A. Goate, T. Grabowski, N. Graff-Radford, R. Green, J. Growdon, H. Hakonarson, James R. Hall, R. Hamilton, O. Harari, John Hardy, L. Harrell, Elizabeth Head, Victor Henderson, Michelle Hernandez, T. Hohman, L. Honig, R. Huebinger, M. Huentelman, Christine M. Hulette, Bradley T. Hyman, L. Hynan, L. Ibañez, Gail P. Jarvik, S. Jayadev, Lee‐Way Jin, Kim Johnson, L. Johnson, M. Kamboh, A. Karydas, M. Katz, J. Kauwe, Jeffrey A. Kaye, C. Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W. Kowall, Joel H Kramer, W. Kukull, Frank LaFerla, J. Lah, Eric B. Larson, Alan J. Lerner, James B. Leverenz, A. Levey, Andrew P. Lieberman, Richard B. Lipton, Mark A Logue, Oscar L. Lopez, K. Lunetta, Constantine G. Lyketsos, Douglas Mains, Flanagan E. Margaret, D. C. Marson, Eden R. Martin, F. Martiniuk, D. Mash, E. Masliah, P. Massman, Arjun V. Masurkar, W. McCormick, S. McCurry, Andrew N. McDavid, Stefan McDonough, Ann C Mckee, M. Mesulam, Bruce L. Miller, C. Miller, Joshua W. Miller, Thomas J. Montine, E. Monuki, John C. Morris, S. Mukherjee, Amanda J. Myers, Trung Nguyen, Sid E. O'Bryant, J. Olichney, Marcia G. Ory, Raymond Palmer, Joseph E. Parisi, Henry L. Paulson, V. Pavlik, D. Paydarfar, Victoria Perez, Elaine R. Peskind, Ronald C. Petersen, A. Pierce, Marsha S Polk, Wayne W. Poon, Huntington Potter, L. Qu, M. Quiceno, Joseph F. Quinn, A. Raj, Murray M. Raskind, E. Reiman, B. Reisberg, Joan S. Reisch, J. Ringman, Erik D. Roberson, Monica Rodriguear, E. Rogaeva, H. Rosen, Roger N. Rosenberg, D. Royall, M. Sager, Mary Sano, A. Saykin, Julie A. Schneider, Lon S. Schneider, W. Seeley, S. Slifer, Scott Small, Amanda G. Smith, Janet Smith, J. Sonnen, S. Spina, Peter St George-Hyslop, Robert A. Stern, Alan B Stevens, Stephen Strittmatter, D. Sultzer, Russell H. Swerdlow, Rudolph E Tanzi, J. Tilson, J. Trojanowski, Juan C. Troncoso, D. Tsuang, V. V. Van Deerlin, Linda J. van Eldik, Jeffery M Vance, B. Vardarajan, R. Vassar, H. Vinters, J. Vonsattel, Sandra Weintraub, K. Welsh-Bohmer, Patrice L. Whitehead, Ellen M. Wijsman, Kirk C. Wilhelmsen, Benjamin Williams, J. Williamson, Henrik Wilms, T. Wingo, Thomas Wisniewski, R. Woltjer, Martin Woon, Clinton B. Wright, chuang-Kuo Wu, Steven G. Younkin, chang-en Yu, Lei Yu, Xiongwei Zhu, B. Kunkle, William S Bush, Li-San Wang, L. Farrer, J. Haines, Richard Mayeux, M. Pericak-Vance, Gerard D. Schellenberg, G. Jun, C. Reitz, A. Naj +270 moresemanticscholar +1 more sourceGenetics of Phenylketonuria: Then and Now
Human Mutation, 2016 More than 950 phenylalanine hydroxylase (PAH) gene variants have been identified in people with phenylketonuria (PKU). These vary in their consequences for the residual level of PAH activity, from having little or no effect to abolishing PAH activity ...N. Blausemanticscholar +1 more sourceIntegrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar +13 morewiley +1 more sourceYAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna +9 morewiley +1 more sourceOmics data reveal the unusual asexual-fruiting nature and secondary metabolic potentials of the medicinal fungus Cordyceps cicadae
BMC Genomics, 2017 Background Ascomycete Cordyceps species have been using as valued traditional Chinese medicines. Particularly, the fruiting bodies of Cordyceps cicadae (syn. Isaria cicadae) have long been utilized for the treatment of chronic kidney disease.Yuzhen Lu, Feifei Luo, Kai Cen, Guohua Xiao, Ying Yin, Chunru Li, Zengzhi Li, Shuai Zhan, Huizhan Zhang, Chengshu Wang +9 moredoaj +1 more sourcePredictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more source
