Results 81 to 90 of about 519,503 (373)
Tractable diffusion and coalescent processes for weakly correlated loci [PDF]
, 2015 Widely used models in genetics include the Wright-Fisher diffusion and its moment dual, Kingman's coalescent. Each has a multilocus extension but under neither extension is the sampling distribution available in closed-form, and their computation is ...
Fearnhead, Paul +2 more
core +3 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
iScience, 2019 Summary: We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter assays
Casimiro Castillejo-Lopez +8 more
doaj
A genome-wide survey of genetic variation in gorillas using reduced representation sequencing [PDF]
, 2013 All non-human great apes are endangered in the wild, and it is therefore important to gain an understanding of their demography and genetic diversity. To date, however, genetic studies within these species have largely been confined to mitochondrial DNA and a small number of other loci.
arxiv +1 more source
An approximate sampling formula under genetic hitchhiking [PDF]
Annals of Applied Probability 2006, Vol. 16, No. 2, 685-729, 2005 For a genetic locus carrying a strongly beneficial allele which has just fixed in a large population, we study the ancestry at a linked neutral locus. During this ``selective sweep'' the linkage between the two loci is broken up by recombination and the ancestry at the neutral locus is modeled by a structured coalescent in a random background.
arxiv +1 more source
A Genetic Approach to the Recruitment of PRC2 at the HoxD Locus
PLoS Genetics, 2013 Polycomb group (PcG) proteins are essential for the repression of key factors during early development. In Drosophila, the polycomb repressive complexes (PRC) associate with defined polycomb response DNA elements (PREs). In mammals, however, the mechanisms underlying polycomb recruitment at targeted loci are poorly understood.
Patrick Schorderet +7 more
openaire +7 more sources
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
The Genetic Determinism of Biochemical Systems Polymorphous From the Blood Serum in Pigs
Scientific Papers Animal Science and Biotechnologies, 2023 The study of genetic markers and identification of new markers make the subject of an increasing number of research projects in various fields such as genetics of immunology, biochemical genetics, molecular genetics, quantitative genetics and the genetic
Nicoleta Işfan +5 more
doaj
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. [PDF]
PLoS Genetics, 2009 There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of alpha(1)-antitrypsin, which is present in 1-2% of individuals with COPD.
Sreekumar G Pillai +18 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 SINE-VNTR-Alu retrotransposons represent one class of transposable elements which contribute to the regulation and evolution of the primate genome and have the potential to be involved in genetic instability and disease progression.
Alexander Fröhlich +6 more
doaj +1 more source