Results 31 to 40 of about 3,082 (288)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Toujours est-il que (p) ou le retour à un topique antérieur
Discours, 2015 In this paper, we propose a semantic and pragmatic analysis of the French lexicalized expression toujours est-il que which marks a return to the main discourse topic (Van Dijk, 1976; Charolles, 2003).
Véronique Lenepveu
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
magazén, 2023 This paper sheds light on the connections between musical undergrounds and the global emergence of ‘goblin mode’ as a political aesthetic. In March 2022 The Guardian published an article discussing the popularity of a new locution emerging on social ...
Monteanni, Luigi
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Réflexions sur la notion de locution conjonctive
, 1988 Gross Gaston. Réflexions sur la notion de locution conjonctive. In: Langue française, n°77, 1988. Syntaxe des correcteurs, sous la direction de Gaston Gross et Mireille Piot. pp.
Gross, Gaston
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Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
La locution in corpore à l'époque mérovingienne
, 1910 Prou Maurice. La locution in corpore à l'époque mérovingienne. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 54ᵉ année, N. 6, 1910. pp.
Prou, Maurice
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FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source