Results 201 to 210 of about 61,463 (315)

Influence of molecular shape and hydrogen bonding on glycolipid self-assembly into thermotropic gyroid phases. [PDF]

Chem Sci
Das S, Zheng C, Lodge TP, Siepmann JI, Calabrese MA, Reineke TM.   +5 more
europepmc   +1 more source

EXPRESSION OF CONCERN: DIMP53‐1: A Novel Small‐Molecule Dual Inhibitor of p53–MDM2/X Interactions with Multifunctional p53‐Dependent Anticancer Properties

Molecular Oncology, EarlyView.
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The Ventral Pallidum Innervates a Distinct Subset of Midbrain Dopamine Neurons. [PDF]

eNeuro
Yang OJ, Elam HB, Lilly K, McCoy AM, Klepikova V, Perez SM, Lodge DJ.   +6 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

First record of Spirometra spp. eggs in fecal samples from Panthera onca in the Brazilian Pantanal: a One Health approach. [PDF]

Rev Bras Parasitol Vet
Raad P, Alencar Junior FP, Pacheco RC, Bressan SF, Lins JGG, Fornazari F.   +5 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Concavity of the maximal expiratory flow-volume curve, and incidence of COPD and respiratory symptoms: a population-based cohort study. [PDF]

ERJ Open Res
Tan DJ, Johns DP, Lodge CJ, Bui DS, Vicendese D, Hamilton GS, Han MK, Agusti A, Abramson MJ, Perret JL, Dharmage SC, Walters EH.   +11 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Increasing the capacity of community managed organisations to provide chronic disease preventive care to people with a mental health condition: protocol for a cluster-randomised controlled trial. [PDF]

BMC Public Health
Love S, Fehily C, Ampofo A, Ryall J, Marasha F, Latter J, Lodge S, Jackson B, Campbell E, Oldmeadow C, Wynne O, Orr M, Govindasamy S, Bowman J.   +13 more
europepmc   +1 more source