Results 111 to 120 of about 226,214 (291)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

All That Sprawl, Y’all: An Analysis of Development on Steinwehr Avenue and York Street in Gettysburg, Pennsylvania, from 1971 to 2014

, 2014
The advent of the automobile transformed the American landscape in the 20th century. In conjunction with the increasing importance of the automobile, numerous post-WW II government programs such as the Interstate Highway System encouraged suburban sprawl.
Emmons, Elizabeth K., Hansel, Kalley S., Simpson, Daly   +2 more
core  

Wildlife Tourism and the Gulf Coast Economy [PDF]

, 2013
The U.S. Gulf Coast is endowed with exceptional natural beauty and ecological diversity, including wetlands, waters, beaches, forests, and all the wildlife that inhabit them.
Marcy Lowe, Shawn Stokes
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Heirloom Winter Wheat Variety Trial [PDF]

, 2017
In 2017, the University of Vermont Extension Northwest Crops and Soils Program evaluated 20 heirloom winter wheat varieties to determine which varieties thrive in organic production systems in northern Vermont.
Cummings, Erica, Darby, Heather, Emick, Hillary, Gupta, Abha, Ruhl, Lindsey, Ziegler, Sara   +5 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Coupling GEDI LiDAR and Optical Satellite for Revealing Large‐Scale Maize Lodging in Northeast China

Earth's Future
Wind‐induced crop lodging can reduce agricultural production and impact food security. However, a systematic evaluation of large‐scale crop lodging and its drivers is lacking, mostly due to the limited observations available.
Qiang Zhang, Geli Zhang, Yao Zhang, Xiangming Xiao, Nanshan You, Zhichao Li, Hao Tang, Tong Yang, Yuanyuan Di, Jinwei Dong   +9 more
doaj   +1 more source

Optimizing sowing dates increase solar radiation to mitigate maize lodging and yield variability: A five-year field study

Journal of Integrative Agriculture
Optimizing sowing dates (SDs) represents a viable strategy for adapting maize production to climate change and enhancing yield. However, research remains limited regarding the integrated effects of lodging and yield in relation to climatic variables ...
Xinglong Wang, Fan Liu, Nan Zhao, Xia Du, Pijiang Yin, Tongliang Li, Tianqiong Lan, Dongju Feng, Fanlei Kong, Jichao Yuan   +9 more
doaj   +1 more source