Results 61 to 70 of about 226,214 (291)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
THE IMPACT OF THE TOURISM SECTOR ON THE VERMONT ECONOMY: THE INPUT-OUTPUT ANALYSIS [PDF]
There are only few states in the United States where state income relies heavily on tourism industry, and Vermont is one of them. Vermont has the advantage in possessing spectacular landscape, clean environment, and attractive agriculturally based rural ...
Halbrendt, Catherine K. +3 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Remote Sensing, 2019 Unmanned aerial vehicles (UAVs) open new opportunities in precision agriculture and phenotyping because of their flexibility and low cost. In this study, the potential of UAV imagery was evaluated to quantify lodging percentage and lodging severity of ...
Norman Wilke +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Management accounting in Portuguese hotel enterprises : the influence of organizational and cultural factors [PDF]
, 2011 Management accounting has evolved in order to respond to the increasing challenges imposed by the hotel and lodging industry This study as the objective of characterizing management accounting in the Portuguese lodging industry, particularly in hotels,
Arroteia, Nuno +2 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
INFLUENCE OF LODGING OF RICE DURING VEGETATION ON RICE MILLING YIELD AND QUALITY
Journal of Agriculture and Plant Sciences, 2017 Depending on the time of lodging of rice during vegetation the yield and the quality of white rice has been putted under analysis of San Andrea variety.
Verica Ilieva +5 more
doaj