Results 91 to 100 of about 66,966 (283)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Eräiden kevätviljalajikkeiden laonkestävyystekijöistä [PDF]
, 2002 vokKirjasto Aj-kOn the factors affecting resistance to lodging in some varieties of spring ...
Multamäki, K
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Recurrent selection for lodging resistance in oats
, 2018 The objectives of this study were (a) to determine the efficiency of two cycles of recurrent selection for the lodging resistance factor (cL,) in an oat population and (b) to determine the effect of selection for cL, on other plant traits. The base population (CO) consisted of 295 SO.l oat lines from the fifth cycle of a line of descent that had been ...
openaire +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Agronomic characteristics of the spring forms of the wheat landraces (einkorn, emmer, spelt, intermediate bread wheat) grown in organic farming [PDF]
, 2010 Organic farmers look to the possibilities of growing neglected crops, such as the spring forms of hulled wheat – einkorn, emmer and spelt – for support in developing the organic farming system.
D Cudney +20 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Evaluation of Drought Tolerance in Arkansas Cowpea Lines at Seedling Stage [PDF]
, 2019 Cowpea [Vigna unguiculate (L.) Walp.] is not only a healthy, nutritious and versatile leguminous crop, it also has a relatively high adaptation to drought.
Cui, Qirui
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Performance of Agronomic Crop Varieties in Alaska 1978 –2002 [PDF]
, 2004 There is no such thing as the perfect variety for Alaska. Some varieties are adapted to a wide range of climatic and geographic locations, while others are more specific in their adaptation.
Knight, Charles W. +1 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source