Results 71 to 80 of about 130,902 (295)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Impact of PCSK9 loss-of-function genotype on 1-year mortality and recurrent infection in sepsis survivorsResearch in context

EBioMedicine, 2018
Background: Reduced activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) has been associated with decreased short-term death in patients with septic shock.
Kelly Roveran Genga, Cody Lo, Mihai S. Cirstea, Fernando Sergio Leitao Filho, Keith R. Walley, James A. Russell, Adam Linder, Gordon A. Francis, John H. Boyd   +8 more
doaj   +1 more source

Essays on expectations and the econometrics of asset pricing [PDF]

, 2013
The way in which market participants form expectations affects the dynamic properties of financial asset prices and therefore the appropriateness of different econometric tools used for empirical asset pricing.
Lof, Matthijs
core  

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Pengaruh Pupuk Organik Cair Kulit Pisang Kepok pada Pertumbuhan dan Produksi Okra (Abelmoschus esculentus)

Jurnal Ilmu Pertanian Indonesia
The content in banana peels, namely protein, calcium, phosphorus, magnesium, sodium, and sulfur, has the potential to be used as liquid organic fertilizer (LOF).
Elfarisna Elfarisna, Annisa Rachman, Erlina Rahmayuni   +2 more
doaj   +1 more source

Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway [PDF]

, 2020
We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells during fracture repair.
Abu-Amer, Yousef, Guan, Jianjun, Jin, Hongting, O\u27Keefe, Regis, Shen, Jie, Tong, Peijian, Wang, Cuicui, Xu, Taotao, Ying, Jun   +8 more
core   +1 more source

Infantile‐Onset Ascending Hereditary Spastic Paraplegia due to a Homozygous ALS2 Exons 24–25 Deletion: Expanding the Genotypic Spectrum

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a novel homozygous intragenic deletion in the ALS2 gene in an 8‐year‐old boy with Infantile‐onset Ascending Hereditary Spastic Paraplegia (IAHSP) and oculomotor apraxia, thereby contributing to the expanding genetic landscape of ALS2‐related disorders.
Vito Luigi Colona, Maria Gnazzo, Silvia Genovese, Gessica Vasco, Lorena Travaglini, Maurizio Sabbadini, Marina Macchiaiolo, Francesco Nicita, Jacopo Sartorelli, Carmelo Piscopo, Enrico Castelli, Enrico Bertini, Andrea Bartuli, Antonio Novelli, Gessica Della Bella, Davide Vecchio   +15 more
wiley   +1 more source

Growth And Yield Of Lettuce (Lactuca sativa L.) Under Organic Cultivation

Planta Tropika: Jurnal Agrosains, 2017
This research was aimed to know selected assemblies of technology in organic lettuce cultivation based on liquid organic fertilizer and selected botanical pesticide.  It used a Complete Randomized design (CRD) with two treatments and 16 replicates.
Mujiono Mujiono, Suyono Suyono, Purwanto Purwanto   +2 more
doaj  

Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes

Genome Medicine, 2022
Background Alzheimer disease (AD) is a common complex disorder with a high genetic component. Loss-of-function (LoF) SORL1 variants are one of the strongest AD genetic risk factors. Estimating their age-related penetrance is essential before putative use
Catherine Schramm, Camille Charbonnier, Aline Zaréa, Morgane Lacour, David Wallon, CNRMAJ collaborators, Anne Boland, Jean-François Deleuze, Robert Olaso, ADES consortium, Flora Alarcon, Dominique Campion, Grégory Nuel, Gaël Nicolas   +13 more
doaj   +1 more source

Anomaly identification of foundation uplift pressures of gravity dams based on DTW and LOF

, 2018
Anomaly can provide valuable information for dam safety monitoring. In this paper, a methodology integrating dynamic time warping and local outlier factor to identify anomalies of time series on various time scales is proposed.
Jiang Hu, Fuheng Ma, Suhua Wu
semanticscholar   +1 more source