Results 121 to 130 of about 136,469 (280)

The Arcsine Log-Logistic Distribution and Its Applications

European Journal of Mathematics and Statistics
This article introduces Arcsine Log-logistic (AL-L) distribution which is a member of Arcsine-G family proposed by Rahman. The different properties of AL-L distribution have been discussed. The distribution of various order statistics are obtained. Maximum Likelihood Estimation (MLE) technique is used to estimate the model parameters.
Md. Aftab Moral, Md. Shohel Rana, Md. Mahabubur Rahman   +2 more
openaire   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Orbitally Stability of Log-Logistic Autoregressive Model with Application

Tikrit Journal of Pure Science
This research aims to study and finding the conditions for stability of the limit cycle of the proposed model (Log-Logistic autoregressive) based on the cumulative function of the Log-Logistic distribution.
Mohammed A. Hamad, Azher A. Mohammad
doaj   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

The Odd generalized exponential log-logistic distribution group acceptance sampling plan

, 2019
In this manuscript, a group acceptance sampling plan (GASP) is developed when the lifetime of the items follows odd generalized exponential log-logistic distribution (OGELLD), the multiple number of items as a group can be tested simultaneously in a ...
Kalyani, Kruthiventi, Rao, Gadde Srinivasa, Kanaparthi, Rosaiah, Sivakumar, Devireddy Charana Udaya   +3 more
core   +1 more source

Detecting Clinical Risk Shift Through log–logistic Hazard Change-Point Model

Mathematics
The change–point problem is about identifying when a pattern or trend shifts in time–ordered data. In survival analysis, change–point detection focuses on identifying alterations in the distribution of time–to–event data, which may be subject to ...
Shobhana Selvaraj Nadar, Vasudha Upadhyay, Savitri Joshi   +2 more
doaj   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source

Different Classical and Bayesian Methods of Estimation of the Power Log-Logistic Distribution with Applications

Axioms
A new approach in constructing a univariate absolutely continuous probability model via power transformation is adopted. The proposed distribution appears to subsume several popular univariate continuous probability models that are already existent in ...
Indranil Ghosh, Devendra Kumar, Subhankar Dutta   +2 more
doaj   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source