Results 51 to 60 of about 61,101 (268)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Classification Evaluation Method for Complex Reservoirsin Xinglong Structural Belt

Cejing jishu
The reservoir of Linhe formation in the Xinglong tectonic belt of the Hetao basin is controlled by low geothermal temperature and late deep burial, with obvious weak diagenetic characteristics, strong heterogeneity of the reservoir, and complex pore ...
LI Xiaofeng, CAI Jun, XIAO Chengwen, CAI Wenyuan, YU Weigao, FU Shaoqing, GUO Yuqing   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Two-dimensional NMR characterization of gas–water distribution in tight sandstone reservoirs: a case study from the Ordos Basin, China

Frontiers in Earth Science
Tight sandstone reservoirs exhibit low porosity, low permeability, significant heterogeneity, and complex gas-water distribution patterns, posing significant challenges for conventional logging methods in accurate gas reservoir identification. Incomplete
Ran Zhang, Ran Zhang, Xinyi Chen, Xinyi Chen, Xin Sun, Xin Sun, Xiang Ge, Xiang Ge, Huanfu Du, Huanfu Du, Mengmeng Yao, Mengmeng Yao   +11 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Logging off [PDF]

Current Biology, 2009
SummaryThe illegal removal and sale of tropical timber is one of the most damaging environmental problems, but a company has developed DNA techniques it hopes will better track trees' provenance. Nigel Williams reports.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The Influencing Factors and Calculation Methods of Rock Electrical Parameters of Carbonate Reservoirs

Cejing jishu
The pore structure of carbonate reservoir is much more complex than that of clastic reservoir, and its rock electrical parameters m and n vary widely, which is difficult to obtain accurately, and the fixed rock electrical parameters are used to calculate
WU Guohai, WANG Kun, FENG Lixiang, SUN Qiao, LI Yonggui, YANG ning, YANG Yuanqi, SUN Liguo   +7 more
doaj   +1 more source

The matrix equation \(\log (XY)=\log (X)+\log (Y)\)

Linear Algebra and its Applications, 2010
Let \(X,Y\) be \(n\times n\) complex matrices such that \(X,Y,XY\) have no eigenvalues on \(\mathbb R^-\) and \(\log (XY)=\log (X)+\log (Y)\). The authors prove that if \(n=2\), or if \(n\geqslant 3\) and \(X,Y\) are simultaneously triangularizable, then \(X,Y\) commute. In both cases the problem is reduced to a result in complex analysis.
openaire   +2 more sources