Results 51 to 60 of about 222,440 (307)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Availability and procurement cost analysis of fresh Norway spruce (Picea abies) logging residue chips and needles from regeneration fellings to biorefining in Finland

open access: yesIndustrial Crops and Products
Logging residues of Norway spruce (Picea abies), especially needles with a high extractives content, show potential as a raw material for biorefineries.
Juha Laitila   +4 more
doaj   +1 more source

Application of High-Resolution Core Curve Construction in Logging Lithology Identification

open access: yesCejing jishu, 2023
Stratum lithology identification based on logging curves is an important direction in the interpretation of logging data, it is usually combined with drilling and coring experiments.
YOU Ting   +5 more
doaj   +1 more source

Valuing ecosystem services: A new paradigm shift [PDF]

open access: yes, 2006
The ways in which economists value natural resources has been, and continues to be, a constantly evolving process. At first, only transactions that took place in the marketplace were considered.
Kaval, Pamela
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer   +14 more
wiley   +1 more source

The Impact of increase in energy prices on sectoral costs of production of the Malaysian economy [PDF]

open access: yes, 2007
This paper examines the impact of an increase in the petroleum price on the sectoral costs of production. Three components of costs of production, which comprise domestic materials, imported input, and labour have been identified.
Abdul Rashid, Zakariah   +1 more
core   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

open access: yesArthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy   +9 more
wiley   +1 more source

An Entry Point for Formal Methods: Specification and Analysis of Event Logs

open access: yes, 2009
Formal specification languages have long languished, due to the grave scalability problems faced by complete verification methods. Runtime verification promises to use formal specifications to automate part of the more scalable art of testing, but has ...
Barringer, Howard   +3 more
core   +2 more sources

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