Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang +9 more
wiley +1 more source
Is Vibe Coding a 'Fire of Prometheus' for Non-Developer Clinicians, Especially Clinical Radiologists? [PDF]
Hwang SI +6 more
europepmc +1 more source
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou +14 more
wiley +1 more source
Electroforming-Free, Self-Rectifying Selector-Only Memory With Diffusive Cu-Ion Dynamics for Logic-In-Memory Computing. [PDF]
Kim JK +7 more
europepmc +1 more source
Geometry‐Encoded Actuation as a Structural Interaction Layer in Origami Robots
We present geometry‐encoded actuation (GEA), a design framework that integrates multistable origami with liquid crystal elastomer actuators to encode environmental interactions into autonomous structural responses. GEA enables programmable shape transformation without continuous sensing or complex control, achieving robust adaptive manipulation and ...
Jianshu Zhou +8 more
wiley +1 more source
Design, implementation and validation of a web-based dynamic simulation platform for pumped storage hydropower plant control systems. [PDF]
Zhang C, Liang T, Li Y, Zhang W, Wang Y.
europepmc +1 more source
A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song +5 more
wiley +1 more source
A modular PLC simulation method for virtual replication of a cost-effective industrial automation laboratory. [PDF]
Al-Yaman M +4 more
europepmc +1 more source
Logic programming to predict cell fate patterns and retrodict genotypes in organogenesis. [PDF]
Hall BA, Jackson E, Hajnal A, Fisher J.
europepmc +1 more source

