Results 281 to 290 of about 480,099 (340)

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

open access: yesAdvanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan   +5 more
wiley   +1 more source

Implementing complex nucleic acid circuits in living cells. [PDF]

open access: yesSci Adv
Sun J   +13 more
europepmc   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

open access: yesAdvanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei   +18 more
wiley   +1 more source

A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis

open access: yesAdvanced Science, EarlyView.
This study presents RotEx‐LAMP‐LFA, a fully integrated, battery‐powered, low‐cost point‐of‐care device for rapid cervical cancer risk detection based on HPV16/18 E6/E7 mRNA. Clinically validated, the system demonstrated high sensitivity and specificity, and showed full concordance between self‐collected and clinician‐collected samples, offering a ...
Yuan Gao   +10 more
wiley   +1 more source

Logic programming with sets

open access: yesJournal of Computer and System Sciences, 1987
openaire   +3 more sources

Hinst: Human‐Like Interactive Instinct Enables Robots to Robustly Accomplish Universal Tasks

open access: yesAdvanced Science, EarlyView.
Aiming at current robot limitations of poor flexibility, poor practicality, and poor universality in task accomplishment, the authors report a human‐like interactive instinct (Hinst) and an anthropomorphic robotic system architecture. The Hinst greatly enhances the efficiency and the success rate of robotic manipulation, skill learning, and task ...
Zijian Liao   +4 more
wiley   +1 more source

Semiconducting Nanomaterials for Intrinsically Stretchable Field‐Effect Transistors

open access: yesAdvanced Science, EarlyView.
This review discusses intrinsically stretchable field‐effect transistors, highlighting recent developments in stretchable semiconducting nanomaterials and fabrication methods. Key material strategies and innovative deposition techniques enabling enhanced mechanical elasticity alongside reliable electronic properties are covered.
Seongmin Heo   +4 more
wiley   +1 more source

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