Results 71 to 80 of about 3,359,701 (313)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Logistic LASSO Regression for Dietary Intakes and Breast Cancer

Nutrients, 2020
A multitude of dietary factors from dietary fat to macro and micronutrients intakes have been associated with breast cancer, yet data are still equivocal. Therefore, utilizing data from the large, multi-year, cross-sectional National Health and Nutrition
A. McEligot, Valerie Poynor, R. Sharma, A. Panangadan   +3 more
semanticscholar   +1 more source

Stable tail dependence functions – some basic properties

Dependence Modeling, 2022
We prove some important properties of the extremal coefficients of a stable tail dependence function (“STDF”) and characterise logistic and some related STDFs.
Ressel Paul
doaj   +1 more source

Identifiability of multivariate logistic mixture models [PDF]

, 2014
Mixture models have been widely used in modeling of continuous observations. For the possibility to estimate the parameters of a mixture model consistently on the basis of observations from the mixture, identifiability is a necessary condition.
Han, JiQing, Shi, ZiQiang, Zheng, TieRan
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Mathematical Modeling and Analysis of Tumor Growth Models Integrating Treatment Therapy

Mathematical and Computational Applications
This study presents a comparative analysis of tumor growth models based on logistic, exponential, and Gompertz formulations. Their response to therapeutic intervention is examined to identify which model shows better behavior with minimal decline of ...
Mohsin Kamran, Johari Yap Abdullah, Afaf Syahira Ahmad Satmi, Maya Genisa, Abdul Majeed, Tayyaba Nadeem   +5 more
doaj   +1 more source

An Integrated MC-HFLTS&MAIRCA Method and Application in Cargo Distribution Companies [PDF]

International Journal of Supply and Operations Management, 2019
Cargo transportation is part of the logistic sectors. Both service quality and customer satisfaction are very important for companies which provide cargo transportation services. This study aims to evaluate cargo companies via DMs (customers) preferences
Tuba Adar, Elif Kilic Delice
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Logistic or linear? Estimating causal effects of experimental treatments on binary outcomes using regression analysis.

Journal of experimental psychology. General, 2019
When the outcome is binary, psychologists often use nonlinear modeling strategies such as logit or probit. These strategies are often neither optimal nor justified when the objective is to estimate causal effects of experimental treatments.
Robin Gomila
semanticscholar   +1 more source