Results 201 to 210 of about 467,604 (263)

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

The CIDR-GPG Protocol Improves Reproductive Efficiency in Yaks and Lowers the Body Condition Requirements for Success. [PDF]

Animals (Basel)
Song Z, Cheng J, Wang C, Yin Q, Chen Z, Li R, Yang Y, Ji Y, Li J, Liu Y, Caiwang G, Gao Y, Hua G.   +12 more
europepmc   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Comparative investigation of the incidence of intraoperative seizures with propofol and remimazolam during anesthetic management for awake craniotomy: Retrospective propensity score matching study. [PDF]

Medicine (Baltimore)
Somura Y, Sato T, Takakura M, Ozeki K, Ando T, Akiyama K.   +5 more
europepmc   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

Development and validation of a predictive model for early postoperative pain after cesarean section. [PDF]

Medicine (Baltimore)
Xu P, Huang H, Qiu G, Cheng H, Feng L.
europepmc   +1 more source

Socio-Demographic and Household Environmental Conditions Associated With Prevalence of Diarrheal Disease in Burao, Somaliland. [PDF]

Environ Health Insights
Yosef DK, Hassan MA.
europepmc   +1 more source

Frailty in older maintenance hemodialysis patients: A latent class analysis revealing personalized management. [PDF]

PLoS One
Chen F, Guo X, Wei D, Wang M, Wang J, Xu D, Jin L, Liang S, Li S, Xian X.   +9 more
europepmc   +1 more source

Intelligent pavement management: a machine learning framework for condition classification and maintenance prioritization. [PDF]

Sci Rep
Gupta B, Agrawal M, Narooka P, Panwar D, Anand S.   +4 more
europepmc   +1 more source