Results 221 to 230 of about 1,790,008 (339)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

open access: yesAdvanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu   +7 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

open access: yesAdvanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li   +23 more
wiley   +1 more source

Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis. [PDF]

open access: yesJ Orthop Surg Res
Xue D   +11 more
europepmc   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

open access: yesAdvanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño   +5 more
wiley   +1 more source

Modern contraceptive methods use behaviour among young married women in Urban Ethiopia: a multilevel mixed-effects binary logistic regression analysis. [PDF]

open access: yesBMC Public Health
Tebeje TH   +12 more
europepmc   +1 more source

Multiple logistic regression analysis of the adequacy of ANC services in Ethiopian, 2019 E_DHS (n = 2918).

open access: green
Dessalegn Tamiru (10119704)   +9 more
openalex   +1 more source

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