Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Medication-Related Information on Social Media: Exploring Public Trust, Perceptions of Credibility, and Influence on Behavior. [PDF]
Abdullah AH +3 more
europepmc +1 more source
Logistics Sourcing Strategies in Supply Chain Design
A company's logistics sourcing strategy determines whether it structures and organizeslogistics within the company or company group or integrates logistics upstream and downstreamin the supply chain. First, three different types of logistics sourcing strategies in supply chaindesign are described and the theoretical background for the development of ...
openaire +1 more source
ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray +3 more
wiley +1 more source
Age-Related Patterns in Health Literacy and Health Information-Seeking Behavior in a Korean Population: Cross-Sectional Study. [PDF]
Kwon DH, Kwon YD.
europepmc +1 more source
Interpretable machine learning reveals how composition and processing govern the formation and microstructural burden of Fe‐rich intermetallic compounds in recycled Al–Si–Fe–Mn alloys. By separating morphology selection from morphology‐conditioned burden partitioning, this framework shows that identical Fe contents can yield different intermetallic ...
Jaemin Wang +2 more
wiley +1 more source
Recruitment Source and Participant Retention in a Digital HIV Prevention Intervention for Young Black and Latino Men and Transgender Women: Secondary Analysis of the HealthMpowerment 2.0 Randomized Controlled Trial. [PDF]
Lin WY +7 more
europepmc +1 more source
Autonomous laboratories can now synthesize materials faster than experts can interpret the resulting diffraction data. A probabilistic framework combines refinement‐fit metrics with large language model‐derived chemical reasoning to rank competing phase interpretations and flag those unsuitable for autonomous use.
Olympia Dartsi +7 more
wiley +1 more source
Ranking microbial risk of self-supplied groundwater in urban Indonesia. [PDF]
Hansen P +5 more
europepmc +1 more source
Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais +32 more
wiley +1 more source

