Results 181 to 190 of about 785,854 (287)

Strategic alternate sourcing : development of an integrated logistics supplier

, 2003
This dissertation explores the benefits of supply chain improvements for the wafer fabrication plants in Singapore. Traditionally, wafer fabrication plants in Singapore have relied heavily on the OEM (Original Equipment Manufacturers) for the supply of equipment spares. Studies have shown that prices of spares bought form OEM are higher.
openaire   +1 more source

Compliant Polymeric Sheet‐Based Heat Exchangers

Advanced Science, EarlyView.
This work presents flexible, transparent, and deployable polymer heat exchangers that achieve a heat transfer capacity per cost up to 4x higher than the state of the art, surpassing both metal and other polymer counterparts. The tube‐on‐tube design enables efficient heat transfer without flow occlusion, while the lightweight, corrosion‐resistant, and ...
Richard J. Fontenot, Loic Duggal, Sofia Urbina, Barclay Jumet, Anoop Rajappan, Daniel J. Preston   +5 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Determinants of Under-Five Mortality in Mozambique: Insights From the Demographic and Health Survey 2022/23. [PDF]

Sage Open Pediatr
Enyew EF, Getnet M, Endalew HL, Getahun AB, Mengstie TA, Asefa T, Jemberie MT, Yewodiaw TK, Endale HT, Dessie G.   +9 more
europepmc   +1 more source

Hierarchical Channeled Graphitized Nanoarchitecture as a Diagnostic Platform for Maternal Fever Warning

Advanced Science, EarlyView.
This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin, Ning Li, Heyuhan Zhang, Xufang Hu, Zhiqiang Liu, Chunhui Deng   +5 more
wiley   +1 more source

Social and environmental determinants of Neglected infectious diseases in quilombola communities of the Brazilian Amazon: An epidemiological and machine learning analysis. [PDF]

PLoS Negl Trop Dis
Fernandes da Silva EM, Aquino LS, Maranhão EP, de Oliveira SMS, Quaresma TC, Marinho DF, Gomes Conde VM, do Nascimento VB, Simplício IOB, do Nascimento Martins NV, Honorato M, de Souza AES, de Paula Fernandes F, Galvão EFC, Valentim LA.   +14 more
europepmc   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Early Prediction of Hepatic Decompensation in Cirrhosis Using Optimised XGBoost Models at the Initial Outpatient Hepatology Visit. [PDF]

Liver Int
Grubert Van Iderstine M, Perez S, Jackson GS, Szun T, Stephanson C, Weisshaar M, Minuk GY, Faisal N.   +7 more
europepmc   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Prediction models of adverse outcomes following surgery and radiotherapy for breast cancer: a systematic review. [PDF]

ESMO Real World Data Digit Oncol
Asfour H, Wang B, Zhou H, Al Janapy A, Patel NG, Symonds RP, Talbot CJ, Rattay T.   +7 more
europepmc   +1 more source