Results 221 to 230 of about 783,646 (327)

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Multilevel analysis of improved water utilization and associated factors in Yemen: using 2013 DHS Yemen national dataset. [PDF]

BMC Public Health
Yohannes L, Genet M, Deme S, Yirdaw AA, Melaku MS.   +4 more
europepmc   +1 more source

A verification of periodogram technique for harmonic source diagnostic analytic by using logistic regression

, 2019
Mustafa Manap, Mohd Hatta Jopri, Abdul Rahim Abdullah, Ryas Rafi Karim, M.R. Yusoff, AH Azahar   +5 more
openalex   +2 more sources

CELLama: Foundation Model for Single Cell and Spatial Transcriptomics by Cell Embedding Leveraging Language Model Abilities

Advanced Science, EarlyView.
CELLama is created, a framework that harnesses language models to convert cellular data into “sentences” that represent gene expression and metadata, enabling a universal embedding of cells. Unlike most single‐cell foundation models, CELLama supports scalable analysis and offers flexible applications including spatial transcriptomics.
Jeongbin Park, Sumin Kim, Jiwon Kim, Dongjoo Lee, Sungwoo Bae, Haenara Shin, Daeseung Lee, Hongyoon Choi   +7 more
wiley   +1 more source

Prevalence and associated factors of melasma among pregnant women on antenatal care at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia: an institutional-based cross-sectional study. [PDF]

BMC Pregnancy Childbirth
Seid AS, Befekadu A, Kassa GM, Woldetensay M, Dewau R, Tekletsadik EA.   +5 more
europepmc   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Global Existence of Solutions to a One-Species and Two-Chemicals Chemotaxis System with Singular Sensitivity and Logistic Source

Mustafa Ekici
openalex   +2 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

A Bayesian Semi-Mechanistic Framework for Modelling Antimicrobial Resistance

Srimokla O, Cavany S, Petrie J, Pritchard M, Nebykova A, Aguilar G, Dolecek C, Cooper B.   +7 more
europepmc   +1 more source

Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity. [PDF]

Nat Metab
Ott R, Zapardiel-Gonzalo J, Kreitmaier P, Casteels K, Hommel A, Kordonouri O, Elding Larsson H, Szypowska A, Vatish M, Zeggini E, Knopff A, Winkler C, Ziegler AG, Bonifacio E, Hummel S.   +14 more
europepmc   +1 more source